Results 91 to 100 of about 38,080 (266)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

A Reexamination of the Functions of Fair Value Accounting

open access: yes, 2006
What is the objectives of fair value measurement? Over the past few years a considerable number of studies have been made on that subject, but the problem is still in controversy.
今田, 正
core  

Stosowanie wartości godziwej w Polsce– wyniki badań

open access: yesZeszyty Teoretyczne Rachunkowości, 2009
Wartość godziwa jest jedną z najbardziej kontrowersyjnych kategorii wyceny. Zarówno zakres jej stosowania w sprawozdaniu finansowym, jak i sposoby ustalania, budzą wiele wątpliwości.
Alicja Mazur
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

AUDITING FAIR VALUES IN A SENSITIVE SOCIO-ECONOMICAL CONTEXT [PDF]

open access: yes
The concept of fair value was subject of many debates and disputes in recentyears. These debates have focused mainly on the relevance of the concept, but also on thepractical difficulties in determining reasonable estimates, raising particularly the ...
Nicoleta Farcane   +2 more
core  

Measurement under IAS 40: Fair value model? Evidence from Indonesia [PDF]

open access: yes
This study examines the effect of contractual, asset pricing, and opportunistic motivations on choosing a fair value or cost model for investment properties, as well as how institutional ownership moderates the influence of these three motivations.
Atminis, Sari   +3 more
core   +1 more source

Możliwości zastosowania wartości godziwejw praktyce

open access: yesZeszyty Teoretyczne Rachunkowości, 2009
Wartość godziwa jest stosunkowo nowym miernikiem wartości stosowanym w rachunkowości, bardziej rzetelnym przy wycenie wielu pozycji bilansowych, a w szczególności instrumentów finansowych, niż koszt historyczny.
Ewa Engelgardt
doaj  

Pension accounting and fair value

open access: yes, 2007
The chapter reviews the applicability of the fair value measurement concept to pension assets and liabilities, concluding that difficulties are likely to arise in measuring pension liabilities at far value, owing to the absence of well-developed markets for such liabilities.
openaire   +7 more sources

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Accounting for financial instruments: an investigation of preparer and user preference for fair value accounting

open access: yes, 2005
This research study, motivated by the difference in opinion between the Joint Working Group of Standard Setters (JWGSS) and the Joint Working Group of Banking Associations (JWGBA), generates empirical evidence on preparer and user preferences for fair ...
Tan, Chyi Woan (Rebecca)
core  

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