Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Machine learning models explanations as interpretations of evidence: a theoretical framework of explainability and its implications on high-stakes biomedical decision-making. [PDF]
BMC Med Res MethodolRizzo M +7 more
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Faithfulness of the Fock representation of $C^*$-algebra generated by $q_{ij}$-commuting isometries [PDF]
, 2017 Alexey Kuz'min, Nikolay Pochekai
openalex +2 more sources
IE-MAS: Internal-External Multi-Agent Steering for Controllable Image Captioning. [PDF]
Entropy (Basel)Cai T, Chen C, Lin S, Ju S, Liao X.
europepmc +1 more source
Faithful representations of association schemes
Faithful representations of association schemesEvery character of an association scheme can be considered as a faithful character of some quotient scheme. Also we will show that a faithful character of an association scheme determines a thin closed subset which is cyclic as a finite group. Article PROCEEDINGS OF THE AMERICAN MATHEMATICAL SOCIETY. 139(9):3191-3193 (2011)
openaire
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
An AI Emulator of Holton-Mass Stochastic Sudden Stratospheric Warming with Faithful Dynamical Representation and an Interpretable Latent Structure [PDF]
Daniel Boscu +6 more
openalex +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Representations of extensions of simple groups. [PDF]
Arch MathHarper S, Liebeck MW.
europepmc +1 more source