Results 161 to 170 of about 795,089 (287)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

When multimodal fusion fails: contrastive alignment as a necessary stabilizer for TCR-peptide binding prediction. [PDF]

Bioinformatics
Qi C, Wang W, Fang H, Wei Z.
europepmc   +1 more source

Group representations

, 1992
Part A: Background Material and Part B: Introduction to Group Representations and ...
Karpilovsky, G, Karpilovsky, Gregory
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Beyond transparency: why Traditional Chinese Medicine (TCM) need explainable artificial intelligence (XAI). [PDF]

Chin Med
Zheng W, Tong Y, Huang J, Zhu L, Chai J.
europepmc   +1 more source

Faithful^∗-representations of normed algebras [PDF]

Pacific Journal of Mathematics, 1960
openaire   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Efficient visualization of chemical space. [PDF]

Chem Sci
Surendran A, Zsigmond K, Chen L, Miranda-Quintana RA.   +3 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Faithful Supervised Dimensionality Reduction for Biomedical Data via Decision Geometry. [PDF]

ACM BCB
Wang Z, Zhou Z, Zhan Q, Shen L.
europepmc   +1 more source