Results 101 to 110 of about 83,357 (315)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Metodi di identificazione per le Fake News [PDF]

open access: yes, 2022
Le Fake News si diffondono tramite social network molto velocemente e possono causare diverse conseguenze negative. Nella tesi si sono analizzate alcune delle tecniche disponibili in letteratura per l'identificazione automatica delle Fake News e si e ...
Zanato, Angelica
core  

The Falsifications of Isaac Babel's Manuscripts and Their Recognition [PDF]

open access: yesЛитературный факт
The article is dedicated to the handwritten legacy of Isaac Babel and examines the writer’s letters, inscriptions, and drawings introduced into scientific circulation in the last decade. Based on the analysis of these findings, the article concludes that
Petr A. Druzhinin
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Who falls for fake news? [PDF]

open access: yes
reservedLo scopo di questo lavoro di tesi è analizzare l’importanza dei fattori capaci di moderare la suscettibilità alle fake news. Nello specifico, questo elaborato si pone l'obiettivo di indagare il ruolo di alcuni fattori cognitivi, come la ...
LA FACE, SILVIA
core  

Temporal and Sentimental Analysis of A Real Case of Fake Reviews in Taiwan [PDF]

open access: yes, 2017
Product reviews are important information sources for consumers as they make their purchasing decisions. However, some unethical firms hire fake reviewers to generate biased positive reviews to promote their product and to damage the product reputations ...
Chih-Chien Wang, Min-Yuh Day, Chien-Chang Chen, Jai-Wei Liou   +1 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Fake news : people with greater emotional intelligence are better at spotting misinformation [PDF]

open access: yes, 2021
The spread of misinformation – in the form of unsubstantiated rumour and intentionally deceitful propaganda – is nothing new. Even in antiquity, Antony and Cleopatra were were cast as villains through fake news shared by Octavian.
Anderson, Tony, Robertson, David James
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Digital revolution and fake news [PDF]

open access: yes, 2017
HE digital revolution and its instantaneous short-term benefits have been celebrated and sold to mankind by peddlers of technology as a blessing in our march towards greater efficiency and productivity. This, it is argued, will fulfil our increasing lust
Ahmad Farouk, Azeem Fazwan
core  

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