Results 61 to 70 of about 109,058 (253)
The real fake: Authenticity and the production of space [PDF]
, 2018 Thames Town—an English-like village built in Shanghai—is many places at once: a successful tourist destination, an affluent residential cluster, a city of migrant workers, and a ghost town.
Piazzoni, MF
core +1 more source
Сибирское юридическое обозрение, 2016 The article deals with the problem of criminal responsibility of individuals for the illegal issue or forgery of documents entitling to obtain superpotent or poisonous substances. The author gives examples from judicial practice, makes recommendations on
Mikhail G. Ermakov
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Walailak Journal of Science and Technology, 2014 During the last 2 years, there has been extensive discussion about “hijacked journals being imposed on the academic world by the huge increase in the number of bogus publishers and spurious websites”.
Mehrdad JALALIAN, Hamidreza MAHBOOBI
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Based on C.Bidard’s and E.Klimovsky’s “Switches and Fake switches in methods of production”, an attempt will be made to show if fake switch points (as named) are in fact, and opposite of what Bidard and Klimovsky claim, real switch points.Fake switch ...
Manoudakis, Kosmas
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Fact-Checking Algorithm in Regional Network Media
Виртуальная коммуникация и социальные сети, 2022 The article raises the problem of fake news verification in mass media. Regional media are particularly notorious for poor fact-checking because their reporters often prefer promptness to quality.
Vladlena Y. Komleva, Valentin E. Solomin
doaj +1 more source