Results 31 to 40 of about 2,686,593 (286)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Knowledge, attitude, practice on fall prevention among informal caregivers of older person with dementia – a scoping review

, 2023
Background: Falls are a significant cause of morbidity and mortality in older people with dementia due to declining physical and cognitive abilities, exposing to high fall risk.
Nedunsaliyan, Sankari, Ashari, Asmidawati, Naidu, Thamayanthi, Ibrahim, Rahimah   +3 more
core   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Current state of fall prevention and management policies and procedures in Canadian spinal cord injury rehabilitation

BMC Health Services Research, 2020
Background Preventing patient falls is a priority in tertiary spinal cord injury (SCI) rehabilitation. Falls can result in patient or staff injury, delayed rehabilitation, and hospital liability.
Hardeep Singh, Heather M. Flett, Michelle P. Silver, B. Catharine Craven, Susan B. Jaglal, Kristin E. Musselman   +5 more
doaj   +1 more source

Preventing School Dropout With Secondary Students: The Implementation of an Individualized Reading and Dropout Prevention Intervention [PDF]

, 2011
Society for Research on Educational Effectiveness (March 2011) Jade Wexler, Sharon Vaughn, Greg Roberts, Nicole Pyle, Anna-Mária Fall: Preventing School Dropout With Secondary Students: The Implementation of an Individualized Reading and Dropout ...
Wexler, J., Vaughn, S., Fall, A-M., Roberts, G., Pyle, N.   +4 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Fall Prevention: Who's at Risk?

EDIS, 2005
There are many risk factors associated with falls. Some risks are environmental, like poor lighting. Others relate to diseases people have or medications they take. It’s important to know if you are at high risk of falling.
Sergio Romero
doaj   +5 more sources

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source