Results 21 to 30 of about 464,680 (254)

Elderly users of fall-risk-increasing drug perceptions of fall risk and the relation to their drug use – a qualitative study

Scandinavian Journal of Primary Health Care, 2017
Objective: The aim of the study was to explore how home-dwelling elderly who use fall-risk-increasing drugs (FRIDs) perceive their fall risk and how they relate this to their drug use.
Hege Therese Bell, Aslak Steinsbekk, Anne Gerd Granas   +2 more
doaj   +1 more source

The Fall Risk Assessment and Correlated Factors Among Elderly Inpatients in 2020: A Cross-sectional Study [PDF]

Iranian Rehabilitation Journal, 2023
Objectives: Patient falls are highly prevalent in hospitals, and are considered a complicated challenge. Thus, the present research assessed the prevalence of the fall risk assessment and the correlated factors among elderly inpatients.
Reza Noori, Nasim Khajavian, Leila Sadeghmoghadam, Fatemeh Hosseini Moghaddam, Moosa Sajjadi, Maryam Moradi, Hamideh Mohammadzadeh, Elham Nikkhah Beydokhti   +7 more
doaj  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Targeting Fall Risk in CKD [PDF]

Clinical Journal of the American Society of Nephrology, 2019
High rates of falls and serious fall injuries are documented in multiple studies of patients with CKD, dialysis-dependent and non-dialysis-dependent ([1][1]–[3][2]). A serious fall injury can precipitate functional decline, loss of independence, nursing home placement, and death.
Nancy G, Kutner, C Barrett, Bowling
openaire   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Fall risks and the related factors for the homebound older people with dementia: Evidence from East China

Frontiers in Public Health, 2022
PurposeFalls are a major public health problem, especially for older people. This research aimed to provide a direct illustration of fall risks among the homebound older people with dementia in China, and to identify the risk factors associated with it ...
Xiaoxin Dong, Guanjun Liu, Xiaoxu Yin, Rui Min, Yueming Hu, Yueming Hu   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Patient safety and patients’ fall risk in the pre-hospital phase of emergency medical services

Journal of Education, Health and Sport, 2019
In Poland, falls constitute the major cause of hospitalisation and deaths among all types of accidents. Around 5,000 people die because of that per year (the standardised rate: 8.8. per 100,000 population).
Marcin Mikos, Magdalena Żurowska-Wolak, Zofia Paradowska, Aleksandra Izabela Czerw   +3 more
doaj   +3 more sources