Results 41 to 50 of about 4,261 (257)

Divine Pain as a Missing Piece to the Structure of God’s Holy Love: A Theological Analysis of Forsyth’s Cruciality of the Cross

Perichoresis: The Theological Journal of Emanuel University
This article will engage with the nature and experience of pain as it pertains to the Divine Nature. Acknowledging holiness as a grounding attribute of God, Forsyth’s emphasis of holy love will provide a new lens through which the conception of God’s ...
Xu Zhiqiu
doaj   +1 more source

Wasted GDP in the USA

Humanities & Social Sciences Communications, 2023
Whether or to what extent Gross Domestic Product (GDP) can measure human development is disputed. This article develops a notion of “wasted GDP”, with a case study on the performance of the USA based on analysis of Human Development Index (HDI) data ...
Morten Tønnessen
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

EFFECTS OF POLLUTION AND CLIMATE CHANGE IN TIMIȘOARA MUNICIPALITY AND ITS PERIURBAN AREA [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2020
The preliminary determination of the article is to investigate the effects of pollution and climate change. In this regard, the authors want to highlight that this real and critical issue must take seriously because each of us contributes to pollution ...
Hunor VASS, Teodor MATEOC, Tabita ADAMOV, Dora ORBOI, Nicoleta MATEOC-SÎRB   +4 more
doaj  

Die ‘vyf trane’ as mistieke uitdrukking in die Dialoë van die Dominikaanse non Katharina van Siëna (1347–1380)

HTS Teologiese Studies/Theological Studies, 2021
The ‘five tears’ as mystical expression in the Dialogues of the Dominican nun Catherine of Siena (1347–1380). This article explores the underestimated teaching of the ‘five tears’ as mystical expression in the text Il dialogo (The dialogues, written in ...
Johann Beukes
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source