Results 41 to 50 of about 602,706 (290)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

EFFECTS OF POLLUTION AND CLIMATE CHANGE IN TIMIȘOARA MUNICIPALITY AND ITS PERIURBAN AREA [PDF]

Scientific Papers Series : Management, Economic Engineering in Agriculture and Rural Development, 2020
The preliminary determination of the article is to investigate the effects of pollution and climate change. In this regard, the authors want to highlight that this real and critical issue must take seriously because each of us contributes to pollution ...
Hunor VASS, Teodor MATEOC, Tabita ADAMOV, Dora ORBOI, Nicoleta MATEOC-SÎRB   +4 more
doaj  

Wasted GDP in the USA

Humanities & Social Sciences Communications, 2023
Whether or to what extent Gross Domestic Product (GDP) can measure human development is disputed. This article develops a notion of “wasted GDP”, with a case study on the performance of the USA based on analysis of Human Development Index (HDI) data ...
Morten Tønnessen
doaj   +1 more source

Ruins of the Future: Decaying Urban Landscapes in Richard Jefferies, J.G. Ballard and Angela Carter’s Speculative Fiction (After London, The Drowned World and The Passion of New Eve)

Études Britanniques Contemporaines, 2022
‘Tous les hommes ont un attrait secret pour les ruines’ (Chateaubriand 360) : Chateaubriand’s declaration conforms to his contemporaries’ fascination for the rediscovered ruins of Antiquity, but proves to be still relevant in contemporary speculative ...
Quitterie de Beauregard
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

RUIN AS RESURRECTION: AN INTERSECTIONAL FEMINIST READING OF THE FALLEN WOMAN IN VICTORIAN LITERATURE

International Journal of Humanity Studies
In so-called civilized societies, women who defy traditional norms or engage in “immoral” behavior are harshly judged and excluded. This dynamic is evident in Thomas Hardy’s The Ruined Maid, Augusta Webster’s A Castaway, and Émile Zola’s Nana, where ...
Wenona Bea Javier
semanticscholar   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source