Results 51 to 60 of about 15,577 (239)

Expanded Phenotype Associated With an Intronic PPP1R12A Variant: A Case Report and Literature Review

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal dominant PPP1R12A‐related genitourinary and/or brain malformation syndrome is a recently described multisystem disorder caused by loss‐of‐function variants in the protein phosphatase 1 regulatory subunit 12a (PPP1R12A) gene. To date, 22 affected individuals have been reported with variable brain malformations and genitourinary ...
Emily M. Bland, Amber Nakar Weinstein, Eric C. Kao, Xiaonan Zhao, Monika Weisz‐Hubshman   +4 more
wiley   +1 more source

A high-resolution spatial map of cilia-associated proteins in the human fallopian tube

Nature Communications
Molecular alterations in the fallopian tubes play a pivotal role in the development of cancer and reproductive disorders, yet their molecular landscape at the protein level remains poorly defined.
Feria Hikmet, Andreas Digre, Jan Niklas Hansen, Samantha B. Schon, Emma Lundberg, Matts Olovsson, Mathias Uhlén, Loren Méar, Cecilia Lindskog   +8 more
doaj   +1 more source

Evaluation of women’s aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling

Frontiers in Bioengineering and Biotechnology
The fallopian tubes play an important role in human fertility by facilitating the spermatozoa passage to the oocyte as well as later actively facilitating the fertilized oocyte transportation to the uterus cavity.
Mayssam Nassir, Mattan Levi, Amir Wiser, Natan T. Shaked   +3 more
doaj   +1 more source

How the HTAR will contribute to a value‐based decision‐making for medicinal products across the EU

British Journal of Clinical Pharmacology, EarlyView.
The European Union Health Technology Regulation 2021/2282 (HTAR) introduces joint assessment of health technologies (including medicinal products and medical devices) across EU Member States. It was signed into law in 2021 and came into full force in January 2025.
Roisin Adams, Michal Stanak
wiley   +1 more source

From Metabolic Crisis to Molecular Classification: Multidisciplinary Management of Synchronous Endometrioid Ovarian and Endometrial Carcinomas With Massive Tumor Burden

Cancer Nexus, EarlyView.
Managing massive tumor burden in synchronous endometrioid carcinomas. The graphical abstract summarizes the clinical pathway from presentation with massive ascites, pleural effusion, and critical metabolic abnormalities to multidisciplinary stabilization, surgical management, integrated morphologic–molecular classification, and shared decision‐making ...
Anna Homeniuk, Leena Abdalla, Sharon Fitzgerald   +2 more
wiley   +1 more source

Abdominopelvic Tuberculosis with a Frozen Section Analysis Consistent with Ovarian Cancer

Case Reports in Infectious Diseases, 2017
Pelvic tuberculosis is a type of extrapulmonary tuberculosis. The disease is accompanied by clinical and laboratory findings which may be unspecific and present aspects of other diseases, including gynecological malignancies.
Agrimaldo Martins-Filho, Paula Carolina Arvelos Crispim, Renata Margarida Etchebehere, Cristina da Cunha Hueb Barata de Oliveira, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini   +5 more
doaj   +1 more source

Revolutionizing the female reproductive system research using microfluidic chip platform

Journal of Nanobiotechnology, 2023
Comprehensively understanding the female reproductive system is crucial for safeguarding fertility and preventing diseases concerning women's health.
Jinfeng Yan, Tong Wu, Jinjin Zhang, Yueyue Gao, Jia-Min Wu, Shixuan Wang   +5 more
doaj   +1 more source

Consumed by Abdominal Distention

Arthritis Care &Research, EarlyView.
Abimbola Fadairo‐Azinge, James Grenert, Brian Haas, Mary Margaretten   +3 more
wiley   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Malignant germ cell tumor of fallopian tube with rhabdomyosarcoma: a case report and literature review

Diagnostic Pathology, 2023
Background Mixed germ cell tumors originating from the fallopian tubes are rarely reported, and high-grade rhabdomyosarcoma with differentiated components is even less common.
Liubiqi Zhao, Yan Li, Fang Wang, Xi Zheng, Li He, Lushuang Zhang   +5 more
doaj   +1 more source