Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib
ABSTRACT A physiologically‐based pharmacokinetic (PBPK) model of niraparib and its primary metabolite using a relevant virtual cancer population is reported here. A series of in vitro experiments using liver S9, microsomes, and hepatocytes with various inhibitors and recombinant supersomes demonstrated that niraparib is specifically metabolized by ...
Gareth J. Lewis +3 more
wiley +1 more source
Diagnosis, management and outcomes of incarceration or intussusception of Fallopian tubes following uterine perforation after vacuum aspiration or dilatation and curettage of the uterine cavity: a systematic review of the literature. [PDF]
Stabile G +7 more
europepmc +1 more source
ABSTRACT Purpose This study examined whether the incidence of retained products of conception (RPOC) differs between hormone replacement cycles (HRC) and natural ovulation cycles (NC) in frozen–thawed embryo transfer (FET) pregnancies. Methods We retrospectively analyzed 425 clinical pregnancies following FET at a single center from 2017 to 2021 ...
Akiko Shimada +8 more
wiley +1 more source
Unicornuate Uterus With a Non-communicating Rudimentary Uterine Horn Treated via Laparoscopic Resection With Preservation of Both Ovaries and Fallopian Tubes: A Case Report and Review of the Literature. [PDF]
Alqarni A +3 more
europepmc +1 more source
The immunohistochemical and histologic effects of contrast medium on uterus, fallopian tubes and ovaries, given during hysterosalpingography: rat study [PDF]
Pek E +4 more
europepmc +1 more source
Physiologic 18F-FDG Uptake in the Fallopian Tubes at Mid Cycle on PET/CT
M. Yun +5 more
semanticscholar +1 more source
Optimizing Maternal Microbiome: Role in Improved Conception and Pregnancy Outcome
Maternal microbiome optimization: Minimized risk and simple corrective steps. ABSTRACT Purpose To evaluate the role of optimizing the maternal microbiome in improving pregnancy outcomes, focusing on preconception and early gestation, and to propose practical diagnostic and preventive strategies, particularly in low‐ and middle‐income countries (LMIC ...
Eytan R. Barnea +7 more
wiley +1 more source

