Results 91 to 100 of about 385,160 (293)
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Benjamini-Hochberg (1995) False Discovery Rate (FDR)
, 2019 False Discovery Rate ...
Jennifer Zorotovich
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
False Discovery Rates in Biological Networks
, 2019 The increasing availability of data has generated unprecedented prospects for network analyses in many biological fields, such as neuroscience (e.g., brain networks), genomics (e.g., gene-gene interaction networks), and ecology (e.g., species interaction networks).
Lu Yu +2 more
openaire +3 more sources
Comparison of false discovery rate for different methods.
, 2013 Comparison of false discovery rate for different methods.
Yi Shen (152956) +4 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
structSSI: Simultaneous and Selective Inference for Grouped or Hierarchically Structured Data
Journal of Statistical Software, 2014 The R package structSSI provides an accessible implementation of two recently developed simultaneous and selective inference techniques: the group Benjamini-Hochberg and hierarchical false discovery rate procedures.
Kris Sankaran, Susan Holmes
doaj +1 more source
Comparison of the empirical bayes and the significance analysis of microarrays [PDF]
Microarrays enable to measure the expression levels of tens of thousands of genes simultaneously. One important statistical question in such experiments is which of the several thousand genes are differentially expressed. Answering this question requires
Schwender, Holger +2 more
core
Computing false discovery rate.
Number of identified cycling genes (A) and false discovery rate (B) as a function of harmonic regression p-value thresholds under different |Δϕ| thresholds. Blue: 25°C. Black: 18°C. Our selected thresholds, p ϕ| (PDF)
Rosemary Braun (217862) +6 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source