Results 41 to 50 of about 726,554 (241)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

C-GUARD: Context-Adaptive Conformal Gating for Improving Robustness Against Evasive Windows PE Malware

Future Internet
Machine Learning (ML)-based malware detectors perform exceptionally well on standard benchmarks, but their robustness to evasive malware remains fragile.
Muhammad Imran, Malik Al-Essa, Felice Franchini, Giuseppe Pirlo   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Misclassification costs used for False Negatives (FN).

, 2016
Misclassification costs used for False Negatives (FN).
Sonam Arora (3118176), Vinod Scaria (19350), Salma Jamal (754296)   +2 more
core   +1 more source

False negatives – A false problem in studies of habitat selection?

Ideas in Ecology and Evolution, 2010
Habitat use and resource selection studies based on presence-only data often use simulated locations as a benchmark for comparison with locations where a species has been observed.
André Desrochers, Eliot J. B. Mcintire, Steve G. Cumming, Josh Nowak, Sapna Sharma   +4 more
doaj  

Accuracy of Tumor Bed Biopsy for Predicting Pathologic Complete Response After Chemotherapy Among Women With Breast Cancer: Complete Responders in the Breast Study

JCO Global Oncology, 2023
CRBr study: 14G tumor bed biopsy unreliable pCR predictor (false negatives 42.1%). Need alternatives.
Nisha Hariharan, T. Subramanyeshwar Rao, Senthil Rajappa, C.C.K. Naidu, K.V.V.N. Raju, Veeraiah Koppula, Kamala Sannapareddy, Rashmi Sudhir, Suseela Kodandapani, Daphne Fonseca, Sudha Murthy   +10 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

False Positive and False Negatives - The General Movements Assessment

, 2018
This fact sheet provides information on the General Movements Assessment and false positives and negatives. The Australian Cerebral Palsy Register indicates less than 5% of cerebral palsy diagnosis are false positive results with standardised ...
Lynda McNamara (5207980)
core   +1 more source

Addressing false negatives and positives in eDNA studies

Methods in Ecology and Evolution
Environmental DNA (eDNA) has revolutionized the study of ecology and biodiversity, enabling species detection without direct observation in the environment.
Amal Bajaffer, Lutfi Afiq‐Rosli, Kah Kheng Lim, Sofia Frappi, Michelle‐Nicole Havlik, Diego E. Rivera Rosas, Elisa Laiolo, Carlos Angulo‐Preckler, Carlos M. Duarte   +8 more
doaj   +1 more source