Results 71 to 80 of about 694,176 (262)

GeneWaltz--A new method for reducing the false positives of gene finding

open access: yesBioData Mining, 2010
Background Identifying protein-coding regions in genomic sequences is an essential step in genome analysis. It is well known that the proportion of false positives among genes predicted by current methods is high, especially when the exons are short ...
Misawa Kazuharu, Kikuno Reiko F
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Features of false and true positives.

open access: yes, 2016
Features of false and true positives.
Mei-Hong Zhang (3195720)   +10 more
core   +1 more source

Addressing false negatives and positives in eDNA studies

open access: yesMethods in Ecology and Evolution
Environmental DNA (eDNA) has revolutionized the study of ecology and biodiversity, enabling species detection without direct observation in the environment.
Amal Bajaffer   +8 more
doaj   +1 more source

Tigers, black swans, and unicorns: The need for feedback and oversight

open access: yesForensic Science International: Synergy, 2019
Humans have a decision-making system which is biased to avoid costly false negatives while the criminal justice system is designed to be biased in the opposite way, avoiding costly false positives.
Max M. Houck
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Accurate decisions in an uncertain world: collective cognition increases true positives while decreasing false positives

open access: yes, 2013
In a wide range of contexts, including predator avoidance, medical decision-making and security screening, decision accuracy is fundamentally constrained by the trade-off between true and false positives. Increased true positives are possible only at the
Wolf, M.   +4 more
core   +1 more source

Impact of CrowdGO annotation re-evaluations on calling true and false positives and negatives.

open access: yes, 2022
Sankey plots show the numbers of true or false positive or negative gene-term annotations before (left) and after (right) re-evaluation by CrowdGO (using the CrowdGOFull model) for the three gene ontologies, (A) Molecular Function, (B) Biological Process,
Maarten J. M. F. Reijnders (12542840)   +1 more
core   +1 more source

False recognition in behavioural variant frontotemporal dementia and Alzheimer’s disease – disinhibition or amnesia?

open access: yesFrontiers in Aging Neuroscience, 2016
Episodic memory recall processes in Alzheimer’s disease (AD) and behavioural variant frontotemporal dementia (bvFTD) can be similarly impaired, whereas recognition performance is more variable.
Emma C Flanagan   +21 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

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