Results 111 to 120 of about 5,683,902 (260)

The impact of White Shark (Carcharodon carcharias) sightings and attacks on recreational water use patterns in False Bay [PDF]

, 2013
White sharks (Carcharodon carcharias) are apex predators that play an important role in the structure and functioning of marine ecosystems. However, despite both their ecological importance and threatened conservation status this species is still subject
Engelbrecht, Tamlyn
core   +1 more source

Star Identification Algorithm Based on Dynamic Distance Ratio Matching

Remote Sensing
A star tracker is a widely used celestial sensor in astronomical navigation systems, which calculates the spacecraft’s high-precision attitude by observing stars in space to obtain several star vectors.
Ya Dai, Chenguang Shi, Liyan Ben, Hua Zhu, Rui Zhang, Shufan Wu, Sixiang Shan, Yu Xu, Wang Zhou   +8 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Development of in silico models that define the applicability domains of binary classifiers: An ITSv2-defined approach for identifying skin sensitization hazards

NAM Journal
The applicability domain's definition is important in validating the reliability of toxicity prediction models. However, applicability domains are established in various model formats and situations, and the definition method is still in the research ...
Takaho Asai, Kazuhiko Umeshita, Michiko Sakurai, Shinji Sakane   +3 more
doaj   +1 more source

Disease-Type-Aware Biological Intelligence Layers for Preventing Symptom Marker False Positives in Computational Drug Target Identification

Three-layer biological intelligence system: disease-type-aware target classifier (9 gene families, 119+ genes, 6-step pipeline), tissue expression boolean gate (Human Protein Atlas), and known-target validator. Prevents symptom markers (GABA receptors, ion channels, inflammatory cytokines) from being promoted as drug targets in infectious diseases ...
openaire   +2 more sources