Results 81 to 90 of about 5,683,902 (260)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Sensors, 2016 Ultra-wideband (UWB) radar has been widely used for detecting human physiological signals (respiration, movement, etc.) in the fields of rescue, security, and medicine owing to its high penetrability and range resolution.
Yang Zhang +6 more
doaj +1 more source
Eyewitness identification : improving police lineups for suspects with distinctive features [PDF]
Eyewitnesses‘ descriptions of suspects often refer to distinctive facial features, such as tattoos or scars, and the police have to decide how best to create fair lineups in these circumstances.
Zarkadi, Theodora
core
Antiviral Drug Target Identification and Ligand Discovery
, 2023 This chapter intends to provide a general overview of web-based resources available for antiviral drug discovery studies. First, we explain how the structure for a potential viral protein target can be obtained and then highlight some of the main ...
Patel, Hershna, Sengupta, Dipankar
core +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
A False-Positive-Centric Framework for Object Detection Disambiguation
Remote SensingExisting frameworks for classifying the fidelity for object detection tasks do not consider false positive likelihood and object uniqueness. Inspired by the Detection, Recognition, Identification (DRI) framework proposed by Johnson 1958, we propose a new
Jasper Baur, Frank O. Nitsche
doaj +1 more source
, 2017 Developing effective high throughput screening (HTS) methods is of paramount importance in the early stage of drug discovery. When a protein binding event can be detected via spectroscopy, then absorbance, fluorescence or chemiluminescence based assays can be used to screen for tens of thousands of compounds per day.
openaire +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
RNAhybrid: microRNA target prediction easy, fast, and flexible [PDF]
, 2006 Krüger J, Rehmsmeier M. RNAhybrid: microRNA target prediction easy, fast, and flexible. Nucleic Acids Research.
Krüger, Jan, Rehmsmeier, Marc
core +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source