Results 161 to 170 of about 1,064,760 (292)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Familial risk for bipolar disorder, childhood trauma and anxiety in youth: Behavioral approach and inhibition systems as mediators of risk. [PDF]

J Mood Anxiety Disord
Argyriou E, Almeida JRC, DelBello MP, Jones CR, Bichlmeier A, Weber WA, Siegel-Ramsay JE, Nick TL, Fleck DE, Adler CM, Chibib L, Strakowski SM.   +11 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Survival in familial idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Reis Estrella D, Mancuzo E, De Amorim Correa R, Tibana R, Soares MR, De Castro Pereira CA.   +5 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Novel sporadic c.2687G>T (p.Gly896Val) CYLD mutation in multiple trichoepitheliomas. [PDF]

An Bras Dermatol
Atılan AU, Cetin N.
europepmc   +1 more source

Cortical spreading depression and familial hemiplegic migraine 2015 [PDF]

, 2015
Pietrobon, Daniela
core   +1 more source

Familial koilonychia

Indian Journal of Dermatology, 2010
Prathap Priya, Asokan N
openaire   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genetic Testing and Imaging in Men with Familial History or Genetic Predisposition of Prostate Cancer-Introducing the Prospective "ProFam-Risk" Study. [PDF]

Eur Urol Open Sci
Lakes J, Boschheidgen M, Antoch G, Klett MK, Karger A, Roth R, Redler S, Pai MG, Wieczorek D, Jäger B, Fehm TN, Niegisch G, Rau TT, Albers P.   +13 more
europepmc   +1 more source