Results 91 to 100 of about 4,443,508 (280)

Eje psicosocial familiar: reporte del diseño e implementación de un programa docente para residentes de los programas de postítulo en Medicina Familiar

ARS Medica, 2012
Cada vez más se acepta que la atención integral en salud requiere un foco de abordaje que esté puesto en la persona y su familia y no solo en la enfermedad o sus consecuencias.
Pamela Rojas, Gabriela Soto, Philippa Moore, Paulina Rojas, Javiera Léniz, Gladys Moreno   +5 more
doaj   +1 more source

Investigating familiar interfaces to help older adults learn computer applications more easily [PDF]

, 2011
Many older adults wish to gain competence in using a computer, but many application interfaces are perceived as complex and difficult to use, deterring potential users from investing the time to learn them.
Hollinworth, Nic, Hwang, Faustina
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Artificial intelligence in the prescription of acute medical treatments in primary healthcare – comparison of the performance of family physicians and ChatGPT

BMC Primary Care
Introduction Artificial intelligence (AI) is increasingly being recognized as a transformative force in healthcare, showing significant promise in supporting healthcare professionals.
Bárbara Lemos Pereira Simão, Carolina Moura Pereira, Mariana Jácome, Catarina Oliveira, Laura Martins Ferreira, José Miguel Paiva, Carlos Braga, Carlos Seiça Cardoso   +7 more
doaj   +1 more source

Jovens agricultores do Oeste de Santa Catarina na encruzilhada: entre o rural e o urbano

Agropecuária Catarinense, 2021
Este artigo discute as aspirações dos jovens rurais que vivem em unidades familiares de produção no Oeste de Santa Catarina. Constatou-se que o comportamento dos jovens está mudando em relação às alternativas que se vislumbram para construir sua ...
Dilvan Luiz Ferrari, Milton Luiz Silvestro, Márcio Antonio de Mello, Vilson Marcos Testa   +3 more
doaj  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Initial experimental evidence that the ability to choose between items alters attraction to familiar versus novel persons in different ways for men and women [PDF]

, 2019
Nonhuman species may respond to novel mates with increased sexual motivation (‘The Coolidge Effect1). In humans, novel technological advances, such as online dating platforms, are thought to result in ‘Choice Overload’2.
Ritchie, Kay L., Sculley, Jordan, Watkins, Christopher D.   +2 more
core