Results 131 to 140 of about 165,409 (268)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The ND250 indexes a visual-orthographic familiarity effect in visual word recognition: evidence from Chinese components. [PDF]

Front Psychol
Huang Z, Hao J, Han J, Gu F.
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Smartphone-based detection of subtle memory decline in prodromal Alzheimer's disease. [PDF]

NPJ Digit Med
Polk SE, Clark LR, Basche K, Kleineidam L, Glanz W, Butryn M, Perneczky R, Buerger K, Fliessbach K, Laske C, Spottke A, Schneider A, Wiltfang J, Teipel S, Bartels C, Rostamzadeh A, Janowitz D, Rauchmann BS, Kilimann I, Sodenkamp S, Coenjaerts M, Brosseron F, Wagner M, Frommann I, Stark M, Schmid M, Schott BH, Johnson SC, Jessen F, Düzel E, Berron D.   +30 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A highly sensitive famous face recognition paradigm for prosopagnosia screening. [PDF]

Behav Res Methods
Bate S, Portch E, Dark O, Bennetts R.
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Clinical recognition memory testing in older adults should move beyond accuracy alone. [PDF]

Front Psychol
Kuruvilla MV.
europepmc   +1 more source

Sociedades familiares : (conflitos familiares/societários)

, 2016
Dissertação de mestrado em Direito (Ciências Jurídico-Empresariais / Direito Empresarial), apresentada à Faculdade de Direito da Universidade de ...
openaire   +1 more source