Results 271 to 280 of about 10,136,889 (397)

Epigenetic protein families: a new frontier for drug discovery

Nature reviews. Drug discovery, 2012
C. Arrowsmith, C. Bountra, P. Fish, Kevin Lee, M. Schapira   +4 more
semanticscholar   +1 more source

Family quality of life in the context of Rett syndrome: insights from Brazilian families. [PDF]

J Community Genet
Carlucci NSS, Favilla BP, Nunes BC, de Lima FT, Melaragno MI, Pilotto RF, de Avó LRDS, Germano CMR, Melo DG.   +8 more
europepmc   +1 more source

The new Russian family policy (2007-2020) : from the demographic crisis to the representation of the "traditional" family

, 2020
Svetlana Russkikh
openalex   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Defining joy after a genetic diagnosis: A narrative inquiry. [PDF]

J Genet Couns
Miller JC, Mills R, Swanson DP, Doyle LE, Washington C.   +4 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Safeguarding children and strengthening families through the application and utilization of family group decision making: A systematic review protocol. [PDF]

PLoS One
Ngadhi CM, Wareley S, Joseph P, Johannes C, Spolander G, Roman NV.   +5 more
europepmc   +1 more source

Phylogenetic relationships of the family Congridae and related taxa (Teleostei: Anguilliformes)

, 2016
慎大 櫻井
openalex   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source