Results 51 to 60 of about 776,083 (234)

Refining Intervention Targets in Family-Based Research [PDF]

Perspectives on Psychological Science, 2010
The results from a large body of family-based research studies indicate that modifying the environment (specifically dimensions of the social environment) through intervention is an effective mechanism for achieving positive outcomes. Parallel to this work is a growing body of evidence from genetically informed studies indicating that social ...
Leve, LD, Patterson, G, Harold, GT, Ge, X, Neiderhiser, JM   +4 more
openaire   +3 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Family-Based Interpersonal Psychotherapy: An Intervention for Preadolescent Depression [PDF]

American Journal of Psychotherapy, 2020
Family-based interpersonal psychotherapy (FB-IPT) is an evidence-based psychosocial intervention for depression in preadolescents (ages 8-12 years). Adapted from interpersonal psychotherapy for adolescents with depression and modified for younger children, this therapy includes structured dyadic sessions with preadolescents and their parents, guidance ...
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A stakeholder perspective on the necessary conditions for successfully implementing parenting interventions in Botswana

Frontiers in Public Health
BackgroundEncouraging positive parenting practices through evidence-based interventions is vital for the achievement of SDG target 16.2, which aims to eradicate all forms of violence against children while promoting their safety and mental wellbeing.
Hlengiwe Gwebu, Tendai Elvis Mutembedza, Tendai Elvis Mutembedza, Jacqueline Kilby, Jeldau Rieff, Styn Jamu, Lisa Jamu, Nomsa Monare, Mary Mosenke, Mmannyana Margaret Nonong, Babedi Ncaagae, Yulia Shenderovich, Yulia Shenderovich, Jamie Lachman, Jamie Lachman, Lucie Cluver, Lucie Cluver, Catherine L. Ward, Catherine L. Ward   +18 more
doaj   +1 more source

The cost-effectiveness of a telephone-based intervention to support caregivers of older people discharged from hospital

BMC Geriatrics, 2019
Background A telephone intervention for caregivers of older people discharged from hospital was shown to improve preparedness to care, reduce caregiver strain and caregiver distress.
David Youens, Richard Parsons, Christine Toye, Susan Slatyer, Samar Aoun, Keith D. Hill, Matthew Skinner, Sean Maher, Sue Davis, Rebecca Osseiran-Moisson, Rachael Moorin   +10 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

The Effect of School-Based versus Family-Based Intervention on Weight Loss and Body Mass Index in Obese and Overweight 6-12-Years-Old Boy Students in Yazd City, Iran

مجله دانشکده پزشکی اصفهان, 2020
Background: The purpose of the present study was to compare the effect of school-based versus family-based intervention on weight loss and body mass index (BMI) in obese and overweight students.
Armindokht Shahsanai, Somayeh Shamsaee, Reza Valagohar   +2 more
doaj   +1 more source

Family-based interventions versus standard care for people with schizophrenia

Cochrane Database of Systematic Reviews, 2020
People with schizophrenia often experience long-term psychosocial disabilities and frequent relapse. Family plays a key role in caring for ill relatives, which in turn probably contributes to high levels of distress and burdens for the family. Family-based interventions have been developed and applied to family members and their relatives with ...
Chien, Wai Tong, Ma, Dennis Chak Fai, Bressington, Daniel, Mou, Huanyu   +3 more
openaire   +3 more sources