Results 91 to 100 of about 16,734,816 (407)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Dynamic Scaling Phenomena in Growth Processes

open access: yes, 1995
Inhomogeneities in deposition may lead to formation of rough surfaces, whose height fluctuations can be probed directly by scanning microscopy, or indirectly by scattering.
Barabasi   +27 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Mapping heterogeneity in family planning indicators in Burkina Faso, Kenya, and Nigeria, 2000–2020

open access: yesBMC Medicine
Background Family planning is fundamental to women’s reproductive health and is a basic human right. Global targets such as Sustainable Development Goal 3 (specifically, Target 3.7) have been established to promote universal access to sexual and ...
GBD Local and Small Area Estimation Family Planning Collaborators
doaj   +1 more source

Family Ties: Multigenerational Family Foundation Board Engagement [PDF]

open access: yes, 2017
Based on interviews with CEOs and family board chairs at seven large, multigenerational family foundations, this publication spotlights the governance practices and structures that these family foundations have created to maintain family involvement ...

core  

Family support groups for family members of mentally ill offenders : family expectations and experiences [PDF]

open access: yes, 2018
Family Support Groups (FSGs) are developed for family members of mentally ill offenders. This study investigates family treatment expectations and experiences of an FSG. Family members were interviewed before (n = 20) and after (n = 17) attending an FSG.
Audenaert, Kurt   +3 more
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Sex Education in Family: Study on Children Living Far Apart with The Family

open access: yesJournal of Nonformal Education, 2019
Premarital sex is still a concern for parents and it is not acceptable behaviour in the community. Besides, it can cause infectious diseases, death of young mothers, susceptible to abortion, and other health risks.
Bayu Pradikto, Sofino Sofino
doaj   +1 more source

Family Preservation Journal, 1999, Volume 4, Issue 1. (Entire issue) [PDF]

open access: yes, 1999
Entire issue (large pdf file) Articles include: What Have We Learned from Articles Published in the Family Preservation Journal? Michael J. Holosko, and D.
Family Preservation Journal
core  

FAMILY CERATOPOGONIDAE

open access: yesZootaxa, 2016
Two hundred and thirty five species of Ceratopogonids arranged in 28 genera are listed for Colombia, mostly Culicoides (112 species) and Forcipomyia (50 species). For each listed species, information on type locality, type category and sex, location of type material, species distribution, localities for Colombia and main references, is provided ...
Spinelli, Gustavo Ricardo, Wolff, Marta
openaire   +4 more sources

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