Results 61 to 70 of about 16,782,197 (406)

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

open access: yesFEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää   +2 more
wiley   +1 more source

Work-Family Conflict and Job Satisfaction: the Mediating Role of Person-Organization Fit Study on Employees of the BRI Aceh Region [PDF]

open access: yes, 2016
The objective of this research is to analyze the influence of person–organizationfit (P-O fit) on work–family conflict (WFC) and job satisfaction (JS) relationships atBank Rakyat Indonesia, Aceh Regional in Banda Aceh.
Ibrahim, M. (Mahdani), Yusra, Y. (Yusra)
core  

Community pharmacists' views on providing a reproductive health service to women receiving opioid substitution treatment: A qualitative study using the TDF and COM-B

open access: yesExploratory Research in Clinical and Social Pharmacy, 2021
Background: The absence of menstruation is common in women who use drugs. This can give a belief that conception is unlikely. When stabilised on Opioid Substitution Treatment (OST), fertility often returns, initially without realisation as ovulation ...
N. Alhusein   +4 more
doaj  

Leave and Discharge: Legalising Science of Psychiatry and the Art of Caregiving!!

open access: yesIndian Journal of Social Psychiatry, 2015
The central theme and guiding principles of Mental Health Care Bill (MHCB), 2013 are “individual autonomy and protection of rights” of persons with mental illness. It has endeavored to address the rights of persons with mental illness.
Savita Malhotra, Ruchita Shah
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

open access: yesFEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling   +4 more
wiley   +1 more source

Orbifold Family Unification [PDF]

open access: yes, 2007
We study the possibility of complete family unification in higher-dimensional space-time. Three families of matters in SU(5) grand unified theory are derived from a single bulk multiplet of SU(N) gauge group (N >= 9) in the framework of S^1/Z_2 orbifold ...
G. G. Ross   +10 more
core   +4 more sources

Senyals contradictoris: entendre la reforma de la immigració mitjançant l'evolució de la legislació sobre immigració dels Estats Units d'Amèrica

open access: yesRevista Catalana de Dret Públic, 2010
Aquest estudi posa de manifest els senyals contradictoris transmesos al llarg de la història per la legislació sobre immigració dels EUA. Una característica constant del desenvolupament de la legislació sobre immigració és que ha mostrat signes tant d ...
Jill E. Family
doaj  

Aproximações socioantropológicas sobre a gravidez na adolescência

open access: yesHorizontes Antropológicos, 2002
Este artigo tem o objetivo de discutir a construção da gravidez na adolescência enquanto um problema social. Visa também apresentar e analisar os dados da etapa qualitativa da pesquisa Gravidez na Adolescência: Estudo Multicêntrico sobre Jovens ...
Maria Luiza Heilborn   +8 more
doaj   +1 more source

BCL-2 family members and the mitochondria in apoptosis.

open access: yesGenes & Development, 1999
A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
semanticscholar   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

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