Results 111 to 120 of about 33,762,667 (306)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Stay the course: practitioner reflections on implementing family-based treatment with adolescents with atypical anorexia

Journal of Eating Disorders, 2019
Background Atypical anorexia nervosa (AN) has received minimal empirical attention regarding effective diagnosis and treatment. Family-based treatment (FBT) might be a promising treatment for atypical AN, yet it is unclear as to what adaptations are ...
Gina Dimitropoulos, Melissa Kimber, Manya Singh, Emily P. Williams, Katharine L. Loeb, Elizabeth K. Hughes, Andrea Garber, April Elliott, Ellie Vyver, Daniel Le Grange   +9 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Treatment techniques and outcomes in multidimensional family therapy for adolescent behavior problems

, 2006
The link between treatment techniques and long-term treatment outcome was examined in an empirically supported family-based treatment for adolescent drug abuse.
Aaron Hogue, Samuolis, Jessica, Sarah Dauber, Howard A. Liddle, Hogue, Aaron, Jessica Samuolis, Liddle, Howard A, Dauber, Sarah   +7 more
core   +1 more source

Internal market orientation and work-family balance\ud in family businesses [PDF]

, 2016
This research paper aims at investigating the importance of work-family balance (WFB) on family businesses from Andalusia (Spain) and its impact on job satisfaction and employees’\ud commitment.
Soares, Anabela, González, Jose, González Porras, J, Soares, A, Ruiz-Alba, J., Soares, A., González, J, Ruizalba, Jose, Ruizalba Robledo, José Luis, Vallespín, M, Ruizalba Robledo, Jose, Vallesp�n, M., Ar�n, Mar�a Vallesp�n, González Porras, José Luis, Ruizalba, J, Vallespín, M., Vallespin, Maria, Vallespín Arán, María, Gonz�lez Porras, J.   +18 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

The impact of gambling problems on families [PDF]

, 2014
Summarises the available research about how gambling problems affect family relationships and family members, how families cope with gambling problems, and the assessment and therapy options available to the family members of people with gambling ...
Nicki Dowling
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A conceptual comparison of family-based treatment and enhanced cognitive behavior therapy in the treatment of adolescents with eating disorders

Journal of Eating Disorders, 2019
Background The aim of this paper is to give a conceptual comparison of family-based treatment (FBT), a specific form of family therapy, and enhanced cognitive behavior therapy (CBT-E) in the management of adolescents with eating disorders.
Riccardo Dalle Grave, Sarah Eckhardt, Simona Calugi, Daniel Le Grange   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source