Results 121 to 130 of about 3,068,795 (349)

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Hrabě František Thun-Hohenstein a jeho reflexe rodinné cesty po západní Evropě v letech 1833 až 1835

open access: yesTheatrum Historiae, 2013
The article that is based on travel diaries, personal calendars and correspondence deals with count Franz of Thun-Hohenstein (1809–1870) and his journey to Western Europe (1833–1835). Its main purpose was to visit England, Scotland and Ireland.
Marcela Zemanová-Oubrechtová
doaj  

Direct and indirect effects of work-family conflict on job performance [PDF]

open access: yes, 2008
A model is developed on the effects of work-family conflict on employees’ emotional exhaustion, job satisfaction and job performance based on the role theory and the conservation of resources theory as well as related studies.
Ahmad, Aminah
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

The effectiveness of self-differentiation training on family process and marital intimacy in couples with marital conflict

open access: yesPreventive Care in Nursing and Midwifery Journal
Background: The rising prevalence of marital conflict and its detrimental impact on individual and family well-being underscores the urgent need for effective interventions.
Seyedeh Farzaneh Jafari   +2 more
doaj   +1 more source

Perceived workplace culture as an antecedent of job stress : the mediating role of work-family conflict. [PDF]

open access: yes, 2010
Few studies have tested the mediating effect of work-family conflict on the relationship between workplace culture and job stress. Approach: This study tested a mediation model consisting of job stress as the dependent variable, perceived family ...
Ahmad, Aminah, Omar, Zoharah
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Does Mother Nature Punish Rotten Kids? [PDF]

open access: yes
This paper studies the evolutionary game theory of parent-offspring conflict. It revisits a question posed by Gary Becker in economics and Richard Alexander in biology, namely "when do children act in accord with the reproductive interests of their ...
Carl Bergstrom, Ted Bergstrom
core  

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