Correlation Analysis of Social Support, Family Resilience, and Family Function in Elderly Patients With Chronic Obstructive Pulmonary Disease: The Mediating Roles of Family Resilience. [PDF]
Biomed Res IntYu F, Zhang X, Chang Y, Zhang X, Lu H.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The mediating role of pregnancy-related anxiety in the relationship between maternal family function and prenatal depression: the moderating effect of sleep latency in late pregnancy. [PDF]
BMC PsychiatryLi Y +7 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The chain mediating effect of family function and resilience between cognitive reactivity and depression among postpartum women in China. [PDF]
BMC Pregnancy ChildbirthFu Y, Zhang M, Lin X, Li Y, Huang F.
europepmc +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Mediating effect of dyadic coping between family function and meaning in life in patients with advanced lung cancer. [PDF]
BMC PsycholLiu G, Pan X, Shen C, Pan L, Li Y.
europepmc +1 more source
Status quo and influencing factors of family resilience in patients with Parkinson's disease
Huli yanjiuObjectiveTo investigate the status quo of family resilience of patients with Parkinson's disease，to clarify its influencing factors and action path，and to provide reference for the intervention research of family resilience of patients with Parkinson's ...
ZHANG Xiaoqing +5 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source