Results 91 to 100 of about 1,386,121 (258)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Methodology for integral assessment of territorial epidemiological risk in the context of the evolutionary dynamics of dominant Mycobacterium tuberculosis genotypes

Acta Biomedica Scientifica
Background. Current tuberculosis monitoring methods rely on retrospective analysis and fail to account for the dynamics of the pathogen population's genetic structure.
V. V. Sinkov, S. N. Zhdanova, E. D. Savilov, O. B. Ogarkov   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Cytokines in influenza in children (literature review)

Сибирский научный медицинский журнал
This literature review was compiled according to the data of search engines PubMed, eLIBRARY.RU, Google Scholar using key words influenza, cytokines, children. The article highlights the participation of pro-inflammatory and antiinflammatory cytokines in
E. D. Kazantseva, A. G. Petrova, L. V. Rychkova, M. A. Darenskaya   +3 more
doaj   +1 more source

From Person-Centered to Family-Centered Health Care [PDF]

Physical Therapy, 2017
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Real-Time PCR for the Diagnosis of Tick-Born Infections [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2016
Overall 842 cases of admission due to tick bites in Irkutsk area during 2014 were analyzed. Detection of DNA/RNA of the tick-born encephalitis virus, Lyme borreliosis, monocytic ehrlichiosisand granulocyticanaplasmosis in the human serum and in the ticks
Lyapunov A.V., Hasnatinov M.A., Manzarova E.L., Egorova D.V., Danchinova G.A.   +4 more
doaj  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Does Smartphone Addiction Cause Depression? A Cross-Sectional Study

Addicta: The Turkish Journal on Addictions
The present study aims to evaluate the relationship between smartphone addiction and depression in primary care. Three hundred fifty-two people who participated in our research, designed as a cross-sectional study, filled out the Short Version of the ...
Raziye Şule Gumuştakım, Izzet Göker Kuçuk, Murat Çevik, Celal Kuş, Serdal Kanuncu, Pınar Bilgili   +5 more
doaj   +1 more source