Results 141 to 150 of about 20,066,694 (296)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Determinants of total family charges for health care--United States, 1980 [PDF]

This report addresses a question of importance for policymakers: \u201cWhat are the determinants of the total charges for health care that U.S. families face?\u201d Policymakers\u2019 concerns about this question have two main grounds. First, U.S. health

core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Evaluation of Nutritional Status of Elderly Patients Presenting to the Family Health Center. [PDF]

Pak J Med Sci, 2018
Nazan S, Buket K.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Impact of a Pharmacist-driven Spirometry Clinic Service within a Community Family Health Center: A 5-year Retrospective Review. [PDF]

J Res Pharm Pract, 2018
Cawley MJ, Warning WJ.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Ohio Family Health Survey results; OFHS

, 2009
Public documents: media information for March 16th OFHS forum.; Title from PDF cover (viewed on Apr. 28, 2009).; "3/16/2009"--P. 2 of Background overview, etc.; PowerPoint slides 2-62 from "Taking the pulse of health in Ohio" are printed 4 per page ...

core  

Misbelieves about Intra Uterine Device (IUD) in Isfahan, Iran

Journal of Family and Reproductive Health, 2010
Objective: Despite Intra Uterine Device (IUD) has the advantage of providing long-term contraception and does not require daily attention, only %8 of Iranian women use it.
Leila Manzouri, Pezhman Aghdak, Shahrbanoo Nematollahi, Ashraf Mansouri, Aghdas Aghababaeian, Sedigheh Dehghan Nasiri Dehghan Nasiri   +5 more
doaj  

A study exploring knowledge, attitudes and behaviours towards autism among adults applying to a Family Health Center in Istanbul. [PDF]

North Clin Istanb, 2015
Surmen A, Hidiroglu S, Usta HH, Awiwi M, Oguz AS, Karavus M, Karavus A.   +6 more
europepmc   +1 more source