Results 141 to 150 of about 1,386,121 (258)

Implementation and evaluation of family-based interventions within the Germany-wide Children of Mentally Ill Parents-network: study protocol for three prospective, rater-blinded, cluster-randomized controlled multicenter trials. [PDF]

Front Psychiatry
Paumen T, Leidger A, Ralfs J, Modarressi A, Ozga AK, Möhl A, Daubmann A, Zapf A, Waldmann T, von Gottberg C, Kilian R, Pardey N, Zeidler J, Beeker T, von Peter S, Heinze M, Pawils S, Georg AK, Taubner S, Piwkowska O, Winter SM, Lingnau R, Stammann C, Willms G, Rezvani F, Dirmaier J, Sekler K, Görres B, Gallinat J, Lambert M, Hohmann S, Driessen M, Siniatchkin M, Jessen F, Bender S, Bermpohl F, Heinz A, Correll CU, Rummel-Kluge C, Seidl UW, Möhler E, Domschke K, Fleischhaker C, Jäger M, Noterdaeme M, Guderian F, Jarczok TA, Kölch M, Burghardt R, Kronmüller KT, Klein F, Holtmann M, Fallgatter AJ, Renner TJ, Schulte-Körne G, Platt B, Frodl T, Flechtner HH, Haase C, Mehl S, Becker K, Claus S, In-Albon T, Schlößer R, Englert E, Becker T, Reif A, Berner M, Born S, Bottlender M, Marschall U, Schäfer L, Rocabado S, Krull T, Henkel M, Brinkmann A, Lübke J, Plachetka H, Hüttmann S, Brandt F, Wiegand-Grefe S.   +80 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The impact of professional characteristics and person-centred care on general practitioners' stress levels. Findings from the cross-sectional PACE GP/FP study in 24 European countries. [PDF]

Eur J Gen Pract
Nessler K, Studzinski K, Klemenc-Ketiš Z, Rogers HL, Eide TB, Ares Blanco S, Lingner H, Kreitmayer S, González-Lama J, Van Poel E, Kafadar D, Hoffmann K, Frese T, Assenova R, Ungan M, Vuletić G, Zelko E, Megallón-Botaya R, Tomičić M, Lopez FM, Tsimtsiou Z, Mora MJ, Mahtani V, Wójtowicz E, Windak A, Petriček G.   +25 more
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Understanding wellness in a context of harm: Gaza's Pandemic mental health success and the Palestine Trauma Center. [PDF]

PLOS Glob Public Health
Bayoumi R, Bones O, Altawil M, Wolde B, Parr N.   +4 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

The role of social support in the effectiveness of counseling for international students. [PDF]

Cogent Ment Health
Tan H, Castonguay LG, Janis RA, Hayes JA, Magruder SAN, Chun-Kennedy CL, Scofield BE.   +6 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Profiles of Social Determinants of Health and Change in Diabetes Status Among U.S. Hispanic/Latino Adults: HCHS/SOL, 2008-2024. [PDF]

Diabetes Care
Brown CJ, Roesch SC, Rosas CE, McCurley JL, Cordero C, Trifan G, Testai F, Zhao B, Cai J, Isasi CR, Gallo LC.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source