Results 181 to 190 of about 1,055,978 (265)

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Caregiver support in aging societies: a qualitative metasynthesis informing public health policy. [PDF]

Front Public Health
Galinsky A, Sorkin C, Marfeo E.
europepmc   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Integrating family-based interventions into specialty court programs: qualitative guidance from sex trafficking specialty court participants and their supportive family members. [PDF]

Health Justice
Murnan A, Mahon J, Jackson G, Pate S, Thompson S, Stewart C, Brown J, Manchak S, Butsch Kovacic M.   +8 more
europepmc   +1 more source

On models of health assistance and the program of family health of the Brazilian Health Department

, 2008
Este artículo referencia los tres modelos que inspiraron la construcción del Programa de Salud de la Familia en el Brasil (cubano, ingles y canadiense), observando sus semejanzas y diferencias y comparando con el caso brasileño. Para tanto se construye una relación entre el Sistema Único de Salud (SUS) y la necesidad de una práctica que permita la ...
openaire   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

A family navigator model for foster parents to promote youth mental health wellness: Study development and protocol. [PDF]

Contemp Clin Trials Commun
Boisseau CL, Risser H, Herrera MA, Law C, Martinovich Z, Jean SS, Wang Y.   +6 more
europepmc   +1 more source

A Family Planning Program Using Volunteers as Health Educators [PDF]

American Journal of Public Health and the Nations Health, 1964
openaire   +2 more sources

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

Thirty years of the Family Health Strategy in the Brazilian Unified National Health System: milestones, advances, setbacks and challenges. [PDF]

Cad Saude Publica
Giovanella L, Mendonça MHM, Campos EMS, Vilasbôas ALQ, Aquino R, Facchini LA.   +5 more
europepmc   +1 more source