Results 111 to 120 of about 1,048,289 (265)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Oral health in the family health strategy: perceptions of professionals and family carers: DOI: 10.15343/0104-7809.201016572

O Mundo da Saúde, 2010
The aim of the study was to identify the perception of professional and family carers of ESF regarding oral health care for children up to 2 years old and actions developed for these subjects.
Lidiane da Silva Gomes Oliveira, Débora Dupas Gonçalves do Nascimento, Fernanda Ferreira Marcolino   +2 more
doaj  

Variation in the Surgical Care of Early Stage Melanoma Based on Surgical Subspecialty: Evaluation of Large Healthcare System

Annals of Surgery Open
Objective:. To investigate how different surgeons’ subspecialties comply with treatment guidelines for early stage melanoma. Background:. The National Comprehensive Cancer Network developed evidence-based guidelines for surgical margins, depth of ...
Kristel Lourdault, PhD, DVM, Arthur W. Cowman, BS, Emiliano Reyes, MS, Danny Lascano, MD, Udai S. Sibia, MD, MBA, Brett Crosby, BS, Tyler Aguilar, BS, Deanna Rider, Stacey Stern, MS, Richard Essner, MD, FACS   +9 more
doaj   +1 more source

Family Health Program: scapegoat?

, 2011
De fato, a Estratégia Saúde da Família (ESF) tem sido avaliada. Mais até do que outras práticas, tanto no plano dos cuidados secundários e terciários de saúde quanto no campo da gestão. Isto não invalida a instituição de novos critérios e métodos bem estruturados que deverão ser coerentes com objetivos definidos com clareza, a exemplo da AMQ, uma boa ...
openaire   +1 more source

[The physiotherapist insertion in the family health program].

Ciencia & saude coletiva, 2011
Study of quali-quantitative character that had as its main objective, to map out the physiotherapist insertion in the Family Health Program (PSF) of the cities that compose a Regional Coordination of Health (CRS) in Rio Grande do Sul State. For this, after the identification of the cities that compose the referred coordination and professional ...
Kéllin Daneluz, Delai, Miriam Salete Wilk, Wisniewski   +1 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Knowledge and Awareness of HPV, the HPV Vaccine, and Cervical Cancer Among Women From a Brazilian Community: A Community‐Based Cross‐Sectional Study

Health Science Reports
Background and Aims Cervical cancer (CC) remains a major public health problem despite effective screening and vaccination strategies. This study aimed to assess women's knowledge and awareness of human papillomavirus (HPV), HPV vaccination, and CC in a ...
Alessandra Monteiro Ramos, Cláudia Vicari Bolignani, Leila Bernarda Donato Göttems, Ana Maria Costa, Heleno Rodrigues Corrêa Filho, Wania Maria do Espírito Santo Carvalho, Fábio Ferreira Amorim   +6 more
doaj   +1 more source

Analysis of the indicators of the Family Health Program in the Metropolitan Region of São Paulo. [PDF]

Einstein (Sao Paulo), 2018
Cesar PAM, Liberal MMC, Marvulle V, Zucchi P, Zucchi P.   +4 more
europepmc   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source