Results 161 to 170 of about 20,077,418 (309)
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
N. Elias +5 more
openaire +2 more sources
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
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This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on Feb.
core +1 more source
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A safe and supportive family environment for children: key components and links to child outcomes [PDF]
Aims to understand more about the prevalence of different types of family environments in society and to explore the influence of these environments on different child outcomes. Introduction Families are the mainstay of safety and support for children.
Higgins, Daryl +3 more
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The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
[Work processes in the family health program: crossings and transverses].
A pesquisa teve o objetivo de compreender os desafios éticos da implantação do Programa usando a abordagem qualitativa e discussão focal em grupo. A amostra foi intencional, com integrantes das diferentes equipes PSF do município de Campo Bom (RS): 3 médicos, 3 enfermeiras, 2 técnicas e 4 agentes comunitários de saúde.
Junges, José Roque +4 more
openaire +2 more sources
Adolescent Sexual and Reproductive Health:Report on an Assessment and Review of Training Materials [PDF]
Young people in Tanzania face a range of serious reproductive health risks – from early unwanted pregnancy and unsafe abortion to sexually transmitted infections, including HIV/AIDS.
Ministry of Health,Tanzania, (MOH) +1 more
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