Results 101 to 110 of about 1,055,978 (265)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Probable collagenous gastritis via Epstein–Barr virus reactivation in the setting of coronavirus disease 2019: a case report

Journal of Medical Case Reports
Background Recent biomedical research has shown the unusual, multisystem effects of coronavirus disease 2019 in humans. One specific sequela of a primary severe acute respiratory syndrome coronavirus 2 infection is the reactivation of latent viruses in ...
Ashten Duncan, Ivonne Veli, Dathan Tsosie, Elizabeth Koffler   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Corrigendum to “Indicators of Quality of Clinical Care for Type 2 Diabetes Patients in Primary Health Care Centers in Qatar: A Retrospective Analysis”

International Journal of Endocrinology, 2020
Saleh Attal, Mohamed H. Mahmoud, Muna Taher Aseel, Ady Candra, Paul Amuna, Mohamed Elnagmy, Mostafa Abdallah, Nahed Ismail, Ahmed Hanfy, Dia Albaw, Abdulsalam Albashir, Hisham Elmahdi   +11 more
doaj   +1 more source

A dialectical methodology applied to medical education in a Primary Care syllabus

O Mundo da Saúde, 2013
The essay aims at making public the pedagogical knowledge on the education of undergraduate medical students in the City of São Paulo, Brazil, in Primary Care.
Fernanda Amendola, Wânia Regina Veiga Martines, Mayumi Uchoa Nawa Pagotto, Maria Elisa Gonzalez Manso   +3 more
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Assessment of vitamin D-related knowledge, attitudes and practices among Sultan Qaboos University students in Oman: a cross-sectional study

BMJ Public Health
Background Vitamin D deficiency, a circulating level of 25-hydroxyvitamin D <30 nmol/L, has become an emerging public health issue in recent years.
Rahma Said Al Hadhrami, Rehab Al Kaabi, Hajer Juma Al Shuaibi, Rawan Salim Al Abdulsalam   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Oral health in the family health strategy: perceptions of professionals and family carers: DOI: 10.15343/0104-7809.201016572

O Mundo da Saúde, 2010
The aim of the study was to identify the perception of professional and family carers of ESF regarding oral health care for children up to 2 years old and actions developed for these subjects.
Lidiane da Silva Gomes Oliveira, Débora Dupas Gonçalves do Nascimento, Fernanda Ferreira Marcolino   +2 more
doaj