Results 241 to 250 of about 4,871,569 (364)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Family-History of Cancer-Patients [PDF]

BMJ, 1884
openaire   +2 more sources

Prediction of dyslipidemia using gene mutations, family history of diseases and anthropometric indicators in children and adolescents: The CASPIAN-III study

, 2018
Hamid Reza Marateb, Mohammad Reza Mohebian, Shaghayegh Haghjooy Javanmard, Amir Ali Tavallaei, Mohamadhasan Tajadini, Motahar Heidari‐Beni, Miguel Ángel Mañanas, Mohammad Esmaeil Motlagh, Ramin Heshmat, Marjan Mansourian, Roya Kelishadi   +10 more
openalex   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Huntington's Disease: A Case Report of a Patient With a Positive Family History. [PDF]

Cureus
Nowakowski P, Waska G, Misztela-Lisiecka E, Miernik-Skrzypczak M, Strozak A.   +4 more
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Optimizing Type 1 Diabetes Screening in People With Family History: A German Perspective. [PDF]

J Diabetes Sci Technol
Danne T, Kapellen TM, Widholz SA, Wabitsch M, Ziegler R.   +4 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Disentangling Gut Microbiome Alterations in Children with Cow's Milk Allergy: Impact of Sex, Milk Elimination, and Family History of Allergies. [PDF]

Nutrients
León ED, Moriki D, Artacho A, Pons X, Koumpagioti D, Tsabouri S, Priftis KN, Douros K, Francino MP.   +8 more
europepmc   +1 more source

BRCA mutations among triple negative breast cancer without family history of breast and ovarian cancer: The Modena family cancer clinic experience

, 2019
Eleonora Molinaro, Marta Venturelli, Angela Toss, Claudia Piombino, Elena Barbieri, Luigi Marcheselli, Isabella Marchi, Enrico Tagliafico, Stefano Cascinu, Laura Cortesi   +9 more
openalex   +2 more sources