Results 41 to 50 of about 1,406,007 (316)

Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis: Analysis of an international cohort of 2,335 patients

Frontiers in Medicine, 2022
BackgroundIn pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis.
Márk Félix Juhász, Márk Félix Juhász, Nelli Farkas, Andrea Szentesi, Andrea Szentesi, Andrea Szentesi, Andrzej Wedrychowicz, Andreia Florina Nita, Natália Lásztity, Alexandra Tészás, István Tokodi, Áron Vincze, Bálint Eross, Bálint Eross, Bálint Eross, Ferenc Izbéki, László Czakó, Mária Papp, Péter Hegyi, Péter Hegyi, Péter Hegyi, Andrea Párniczky, Andrea Párniczky, Andrea Párniczky   +23 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Weir Family History - Accession 715 no. 119 [PDF]

, 2015
The Weir Family History was compiled by Mary Lynn Weir in 1979 (number 5 of 50) titled The Weirs: A Scotch Family From Antrim Ireland. The history provides information on the Weirs of Chester County, South Carolina and historical background on the ...
Family History - Weir Family
core  

Family History Research and Distressing Emotions

, 2023
Anecdotal evidence suggests that the popular pastime of exploring one’s family history can unleash strong emotions, both positive and negative. The aim of this study was to chart the extent and nature of negative emotions among family historians ...
Susan M. Moore
core   +1 more source

Between Grandma and Granddaughter – The Process of Becoming a Black Woman in a Racist Society. Analysis of Intergenerational Transmission on the Example of bell hooks’ autobiography Bone Black: Memories of Girlhood

Nauki o Wychowaniu, 2022
The aim of the essay is to discuss an intergenerational transmission of family history and its impact on the process of becoming a Black woman in a racist society.
Aneta Ostaszewska
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting [PDF]

, 2008
: BACKGROUND: An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast cancer screening.
de Bock, Geertruida H.; id_orcid, Seynaeve, C., Krol-Warmerdam Elly MM, Blom Jannet, de Bock, G.H., Cornelisse, C.J., Blom, Jannet, de Bock, GH, Brekelmans, C.T., Asperen, C.J. (Christi) van, Klijn, J.G., Jacobi, Catharina E., Houwelingen, J.C. van, van Asperen Christi J, Krol-Warmerdam, Elly M. M., Devilee, P, Brekelmans, C.T. (Cecile), Brekelmans Cecile TM, Klijn, Jan G. M., de Bock Geertruida H, Krol-Warmerdam, E.M., Krol-Warmerdam, EMM, van Asperen, C.J., Blom, J. (Jannet), Cornelisse Cees J, Jacobi, C.E., Tollenaar Rob AEM, Cornelisse, Cees J., Krol-Warmerdam, E.M.M. (Elly), Tollenaar, R.A., Seynaeve, C.M. (Caroline), Jacobi, CE, Tollenaar, R.A.E.M. (Rob), de Bock, Geertruida H., Blom, J., van Houwelingen, JC, Tollenaar, Rob A. E. M., van Asperen, Christi J., Brekelmans, CTM (Cecile), Bock, G.H. (Geertruida) de, van Asperen, CJ, Klijn Jan GM, van Houwelingen Johannes C, Devilee, Peter, Seynaeve Caroline, Brekelmans, Cecile T. M., Seynaeve, Caroline, Devilee Peter, Klijn, J.G.M. (Jan), Jacobi Catharina E, van Houwelingen, J.C., Klijn, Jan, Jacobi, C.E. (Catharina), Devilee, P. (Peter), Tollenaar, RAEM, Devilee, P., Cornelisse, C.J. (Cees), van Houwelingen, Johannes C., Blom, J, Cornelisse, CJ   +59 more
core   +1 more source

THE HISTORY OF A FEEBLEMINDED FAMILY [PDF]

The Journal of Nervous and Mental Disease, 1916
n ...
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source