Results 91 to 100 of about 2,287 (186)

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

open access: yesAdvanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin   +9 more
wiley   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

open access: yesAdvanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Reactions of roe deer to human disturbances and wolf predation in a Polish forest. [PDF]

open access: yesCurr Zool
Andżelika H   +4 more
europepmc   +1 more source

Canonical Antibodies Adopt Distinct Binding Modes to Recognize Viral Glycan Shields

open access: yesAdvanced Science, EarlyView.
Canonical Y‐shaped antibodies recognize viral glycan shields through adaptive Fab assembly states shaped by glycan organization and somatic hypermutation. Structural analyses ofbroadly neutralizing antibodies VRC35 and VRC36 across glycoproteins of HIV‐1, influenza, SARS‐CoV‐2, and Lassa viruses reveal distinct Fab assembly states, spanning monovalent,
Jiaxuan Cheng   +71 more
wiley   +1 more source

Topology‐Enabled Finite‐Band Absorption Framework Based on a Bioinspired Nested Dual‐Loop Architecture

open access: yesAdvanced Science, EarlyView.
A nuclear‐pore‐inspired nested dual‐loop architecture redistributes electromagnetic energy through coupled transport, confinement, and dissipation pathways. Integrated with Co/Fe3O4 dual‐magnetic composites and topology optimization, the 11‐mm‐thick absorber delivers continuous 2–40 GHz attenuation, raises finite‐band structural utilization to 82%, and
Shaokang Liu   +6 more
wiley   +1 more source

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