Results 201 to 210 of about 4,182,366 (344)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Storylines of family medicine I: framing family medicine – history, values and perspectives

Family Medicine and Community Health
Larry A Green, William B Ventres, Leslie A Stone, Kathleen T Rowland, Richard H Streiffer, Michael D Macechko, Julia A Roulier, Jeffrey M Borkan   +7 more
doaj   +1 more source

Analysis of the increase in the complexity of care in family medicine. [PDF]

BMC Prim Care
Montero-Alía JJ, Seda-Gombau G, Zamora-Sánchez MV, Del Mar Rodríguez-Álvarez M, López-Torrent E, Torán-Montserrat P.   +5 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

ADFM: Update on the National Family Medicine Strategic Plan for Research. [PDF]

Ann Fam Med
Robinson S.
europepmc   +1 more source

QUALITY – THE MAIN VALUE IN THE FAMILY MEDICINE MANAGEMENT

, 2016
Константин Ецко, Ludmila Goma, Н.С. Глоба, Natalia Zarbailov, Galina Tomasz   +4 more
openalex   +1 more source

A Method for Obtaining an Unbiased Sample of Family Medicine Patients for Research Purposes [PDF]

, 2011
E. E. Logue, Claire C. Bourguet
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Z-Drug Use and All-Cause Mortality: A Meta-Analysis of Observational Cohort Studies

Neuropsychiatric Disease and Treatment
Ji-Yeon Park,1 Hye Jin Park,1 Hae-Jin Ko,1,2 A-Sol Kim,2,3 Ji-Eun Song,2,3 Hee-Eun Hong1 1Department of Family Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Family Medicine, School of Medicine, Kyungpook ...
Park JY, Park HJ, Ko HJ, Kim AS, Song JE, Hong HE   +5 more
doaj  

To Teach or Not to Teach: Incentives and Barriers Impacting Clinical Preceptorship in Family Medicine. [PDF]

PRiMER
Mechling D, Brougham H, Rodriguez C, Kendrick J, Johnson M.   +4 more
europepmc   +1 more source