Results 101 to 110 of about 3,847,256 (292)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The lifeworld of families of mental health care users in rural South Africa: A phenomenological study

South African Journal of Psychiatry
Background: In recovery-oriented mental health care, family members of mental health care users form part of the caring team. Families are expected to care for mental health care users without support in the under-resourced rural Vhembe district in South
Takalani E. Mbedzi, Anna E. van der Wath, Miriam M. Moagi   +2 more
doaj   +1 more source

Violența în familie, o nouă țintă a politicii penale populiste [PDF]

Forum Juridic, 2020
The law criticized in this article can be categorised in the area of populist criminal policy, having as object the modification of art. 199 Criminal Code - Domestic violence.
Valerian Cioclei
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The Elderly Expectations of the Caregiver’s Sociodemographic Preferences: a Qualitative Approach

Global Medical & Health Communication, 2019
Prevalence of chronic diseases and disability will increase at the advancing age. In the future, the need for the caregiver will increase. Only few studies about the expectations of the elderly towards the sociodemographics status of the caregiver found.
Sharon Gondodiputro, Dahlia Santika Hutasoit, Lina Rahmiati   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Violența domestică sau violența în familie? Necesitatea unei reglementări unitare în ceea ce privește principalele instituții din domeniul violenței domestice [PDF]

Drepturile Omului, 2020
Constantly concerned with the alignment of national legislation with the requirements of international and European regulations, the legislator has made substantial changes in terms of fundamental notions regulated by Law no.
Georgeta Stoican
doaj  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Translation, cultural debugging, and validation of the Chinese version of the Sour Seven Questionnaire: a cross-sectional study

Frontiers in Medicine
IntroductionIntensive care unit delirium (ICUD) is an acute cerebral dysfunction accompanied by a change of level of consciousness, disorientation, and cognitive dysfunction, typically occurring over a short duration ranging from hours to days and ...
Shichao Zhu, Shichao Zhu, Shiqing Liu, Liming Li, Liming Li, Huanmin Xing, Huanmin Xing, Ming Xia, Ming Xia, Guangyan Dong, Guangyan Dong   +10 more
doaj   +1 more source