Results 31 to 40 of about 1,590 (261)

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Historyczne nazewnictwo osobowe podlaskiego rodu Kiersnowskich w XVI–XVII stuleciu

Zeszyty Cyrylo-Metodiańskie, 2019
Historical Personal Names of the Kiersnowski Family from the Podlasie Region in the 16th–17th Century. The subject of this study is the description of the historical personal names of the Kiersnowski family from the Podlasie region.
Złotkowski, Piotr
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Exploring How Japanese Second Language English Readers Respond to Proper Names

Onomástica desde América Latina, 2022
An assumption in second language (L2) vocabulary and reading research is that L2 readers can easily understand the proper names they encounter, though empirical support for this conjecture is lacking.
Kimberly Klassen
doaj   +1 more source

Family Names and Nicknames of One Village: History, Etymology, Classification

Ukrainian Studies, 2015
The tendencies of simultaneous existence of both family names and nicknames of peasants of Danyna village in Nizhyn District Chernihiv Region are observed in the article. All the necessary information has been collected in the very village by the author himself.
openaire   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

How to publish research on offensive familiy nicknames? Some ethical considerations in anthroponomastics

Folia Onomastica Croatica, 2014
This article discusses ethical considerations regarding the publishing of research on family nicknames. Family nicknames function, unlike surnames, as indices which have not completely lost the transparency of their semantic background and are used as ...
Ines Carović, Kristian Novak
doaj  

Does Contract Farming Improve Diet Quality? The Case of Senegalese Smallholders

Agribusiness, EarlyView.
ABSTRACT The institution of contract farming has gained prominence in most developing countries owing to its numerous benefits. While several studies have already highlighted the welfare benefits of contract farming, very few have investigated the effects on diet quality, despite poor quality diets being a serious challenge in most parts of the ...
Francis E. Ndip, Takeshi Sakurai
wiley   +1 more source

On the Trail of Creativity: Dimensionality of Divergent Thinking and Its Relation With Cognitive Abilities, Personality, and Insight

European Journal of Personality, EarlyView., 2020
Abstract Divergent thinking (DT) is an important constituent of creativity that captures aspects of fluency and originality. The literature lacks multivariate studies that report relationships between DT and its aspects with relevant covariates, such as cognitive abilities, personality traits (e.g. openness), and insight. In two multivariate studies (N 
S. Weiss, D. Steger, Y. Kaur, A. Hildebrandt, U. Schroeders, O. Wilhelm, Christian Kandler   +6 more
wiley   +1 more source