Results 91 to 100 of about 199,117,917 (354)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
MODIFYING ASSESSMENT FOR THE ADVANCEMENT OF FAMILY LAW THEORIES AND PRACTICES
Jurnal Al-DusturFamily law primarily refers to the legal rules that regulate relationships within the family, which can derive from either blood relations or the act of marriage.
Wirani Aisiyah Anwar +3 more
doaj +1 more source
Слово.ру: балтийский акцент, 2017 Translation is a multidimensional phenomenon. All the theories stress the diversity of its types and strategies. Phenomena described as an unexplainable deviation within one theory can form the foundation for another.
Zolyan S.
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Twisted massive non-compact models
Journal of High Energy Physics, 2018 We study interacting massive N = (2, 2) supersymmetric field theories in two dimensions which arise from deforming conformal field theories with a continuous spectrum.
Songyuan Li, Jan Troost
doaj +1 more source
Family Business and Transaction Exposure
Journal of Open Innovation: Technology, Market and Complexity, 2020 This study provides additional evidence and insight into theories on transaction exposure as it empirically examines the magnitude of transaction exposure in Kuwait, a developing country. Specifically, it investigates factors that might influence Kuwaiti
Khalil Nimer +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Background independence of closed superstring field theory
Journal of High Energy Physics, 2018 Given a family of world-sheet superconformal field theories related by marginal deformation, we can formulate superstring field theory based on any of these world-sheet theories.
Ashoke Sen
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source