Results 61 to 70 of about 90,314 (267)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Pengaruh Struktur Kepemilikan Terhadap Profitabilitas Perusahaan Manufaktur di Indonesia

open access: yesJurnal Akuntansi dan Keuangan, 2013
The purpose of this study is to investigate the effect of ownership structure on profitability in the manufacturing sector. Independent variables used for this study are consisted of foreign ownership, government ownership, managerial ownership ...
Yulius Ardy Wiranata   +1 more
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Corporate governance and cash holdings: Family versus non-family controlled firms

open access: yesCogent Business & Management, 2020
We examine the impact of corporate governance on cash holdings and the interplay of family ownership on this relationship through static and dynamic panel estimation models.
Rauf Gul   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

EVOLUTION OF FAMILY BUSINESSES – A 3D THEORETICAL APPROACH [PDF]

open access: yesOradea Journal of Business and Economics, 2020
: According to international literature there are many researches about family businesses. Examining and evaluating these kinds of businesses is a complex task because it is hard to take into account every influencing factor which have an impact on the ...
Júlia Tobak, András Nábrádi
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Hubungan antara Kepemilikan Keluarga dengan Kesuksesan Bisnis pada Usaha Kecil & Menengah (UKM)

open access: yesAkuntansi Dewantara, 2019
The relationship between small firm ownership and performance is an interesting issue, especially in accounting literature. The purpose of this study is to examine whether there are business success differences in SMEs based on ownership.
Arista Natia Afriany   +2 more
doaj   +1 more source

The coexistence of family, ownership, and business: Conceptualizing entanglement and business family ownership

open access: yesWorld Journal of Advanced Research and Reviews
The primary objective of this research is to conduct a detailed analysis of the intricate interplay between family dynamics, ownership structures, and business operations in the context of family-owned firms. The study used a mixed-methods research design, which combines qualitative and quantitative research methodologies.
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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