Results 61 to 70 of about 5,333,777 (348)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Family Ownership, Audit fees, Auditor choice: Evidence from Tehran stock exchange [PDF]

پژوهش‌های حسابداری و حسابرسی عملیاتی و عملکرد, 2017
The purpose of this study is to investigate the relationship between family Ownership and audit fees and auditor choice. The statistical population of this research is the listed companies in the Tehran stock exchange.
حمید رضا وکیلی فرد, رضیه علی خانی, مهدی مران جوری   +2 more
doaj  

THE EFFECT OF TAX AVOIDANCE ON FIRM VALUE: THE MEDIATING ROLE OF AGENCY COST AND MODERATING ROLE OF FAMILY OWNERSHIP [PDF]

, 2018
This study aims to investigate the effect of tax avoidance on firm value with the mediating role of agency cost and moderating role of family ownership. Firm value is measured with Tobin’s Q, tax avoidance was measured with effective tax rate and agency ...
FUAD, Fuad, PRATIWI, Amalia Intan
core  

The Effect Of Family Ownership, Institutional Ownership, Managerial Ownership, Blockholder Ownership, And Board Of Directors On Company Performance

Ratio : Reviu Akuntansi Kontemporer Indonesia, 2022
This study aims to determine the effect of family ownership, institutional ownership, managerial ownership, blockholder ownership, and the board of directors on firm performance that is proxied by ROA (Return On Assets) in industrial companies related to consumer goods companies in the Indonesian Sharia Stock Index (ISSI) years 2015-2018.
Muhammad Rizqi Alriansyah Manurung, Juli Riyanto Tri Wijaya   +1 more
openaire   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Family-Concentrated Ownership in Chinese PLCs: Does Ownership Concentration Always Enhance Corporate Value?

International Journal of Financial Studies, 2014
In this paper we investigate the relationship between family ownership structure and corporate value across a sample of 1314 firm-year observations of China’s family publicly listed companies (PLCs), from 2004 to 2008.
Jin-Hui Luo, Heng Liu
doaj   +1 more source

Does board activeness strengthen the relationship between structure of corporate ownership and firm performance?

Frontiers in Psychology, 2023
This study empirically investigates the moderating effect of board activeness on the relationship between the structure of corporate ownership and firm performance.
Feng Yuan, Rana Tanveer Hussain, Iqra Khalid, Mi Li   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Networked Families [PDF]

, 2008
Presents survey results on the use of the Internet and ownership of cell phones and computers, by household type. Examines how technology ownership affects the frequency, form, purpose, and quality of communications among family members and ...
Aaron Smith, Amy Tracy Wells, Barry Wellman, Tracy L. M. Kennedy   +3 more
core  

The Life Cycle of Family Ownership: International Evidence [PDF]

Review of Financial Studies, 2011
We show that in countries with strong investor protection, developed financial markets, and active markets for corporate control, family firms evolve into widely held companies as they age. In countries with weak investor protection, less developed financial markets, and inactive markets for corporate control, family control is very persistent over ...
Franks, Julian, Mayer, Colin, Volpin, Paolo, Wagner, Hannes   +3 more
openaire   +3 more sources