Results 121 to 130 of about 3,977,981 (306)

Child-Centered Social Support and Families

Kazoku syakaigaku kenkyu, 1999
本稿の目的は、〈子育ち〉の社会的支援のイメージを明らかにするための視点や考え方を提示することである。今日、モノの豊かな社会では、家族がかつて持っていた意図せざる教育力が構造的に失われているため、親の努力だけでは子どもを適切に育てられない。したがって、第一に、我々は子どもがみずから育っていく権利を評価すべきである。第二に、親の子どもに対する権力について自覚的でなければならない。親の権力は、子どもの教育の基盤であると同時に、子どもへの暴力的支配をもたらしうる。第三に、我々は子どもの周りに沢山の家族的な小集団を組織することができる。それは子ども自身を直接的に支援するとともに、結果として親をも支えることになる。このようにして、育児を社会化していくことができよう。
openaire   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The influence of family social support on quality of life of informal caregivers of cancer patients. [PDF]

Nurs Open, 2021
García-Carmona M, García-Torres F, Jacek Jabłoński M, Gómez Solís Á, Jaén-Moreno MJ, Moriana JA, Moreno-Díaz MJ, Aranda E.   +7 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The role of peer social support on family psychological resilience in caring for Chronic Kidney Disease patients receiving hemodialysis

Healthcare in Low-resource Settings
Chronic Kidney Disease (CKD) is a disease that necessitates continuous Hemodialysis (HD) therapy, and families, as primary caregivers in Indonesia, play a crucial role in caring for CKD patients.
Lilik Supriati, Muhammad Sunarto, Ikhda Ulya, Muhammad Rodli, Rendi Yoga Saputra, Renny Nova, Nur Hidaayah   +6 more
doaj   +1 more source

Family social support and the self-esteem of breast cancer patients undergoing neoadjuvant chemotherapy. [PDF]

J Public Health Res, 2021
Aprilianto E, Lumadi SA, Handian FI.
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Family social support and stability of preferences regarding place of death among older people: a 3-year longitudinal study from the Japan Gerontological Evaluation Study. [PDF]

Age Ageing, 2022
Kawaguchi K, Ide K, Kondo K.
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Promoting Social Participation in the Primary Care Field: An Ecological Study on the Potential Reduction of Multimorbidity Prevalence

Journal of Primary Care & Community Health
Background: No municipal-level study has elucidated the social determinants associated with multimorbidity prevalence (MP). Objective: This article aimed to determine the differences in MP among municipalities and investigate factors associated with such
Ryota Takahashi, Tadao Okada, Kazushige Ide, Taishi Tsuji, Katsunori Kondo   +4 more
doaj   +1 more source