Results 61 to 70 of about 2,025,816 (253)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Историческая этнологияThe article is devoted to the study of the system of traditional family values among the Turkic-speaking peoples living in the lowland part of Dagestan.
Madina B. Gimbatova
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Public HealthIntroductionSouth Korea faces a declining total fertility rate (0.72 in 2023) alongside rising infertility rates. Infertility is often interpreted within a pronatalist sociocultural context emphasizing marriage, parenthood, and traditional gender role ...
Miok Kim, Hyeon Sik Chu, Su Jeong Yi
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Models of youth’s family relations in Penza region
Известия высших учебных заведений. Поволжский регион: Общественные наукиBackground. The Russian family is going through a difficult period of its devel-opment, characterized by a number of trends such as the normalization of cohabitation, the postponement of marriage and childbirth, and the popularization of “childfree ...
A.M. Ivanishko
doaj +1 more source
InkanyisoThe erosion of the term ‘Father’ from societal vocabulary reflects a deeper social and spiritual crisis in African communities. This article examines how Christianity and colonialism disrupted African family structures and aims to propose pathways for ...
Sifiso Khuzwayo, Wessel Bentley
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source