Results 91 to 100 of about 2,010,923 (253)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
The study of family upbringing traditions as a potential for preserving spiritual and moral values
Современное дошкольное образованиеBackground. The implementation of the task of introducing children to the traditional moral values of the Russian people, socio-cultural norms and cultural traditions of their families is highlighted among the priorities in the new Federal Educational ...
Irina N. Vorobyeva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Вестник университета, 2019 The article is devoted to the study of family values of pensioners of the Republic of North Ossetia-Alania. The study found that the family is the main value of the older generation.
V. Tarchenko
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The examination of family value hierarchies in Russian and Chinese cultures
Образование и наукаIntroduction. In the context of globalisation and the intensification of international contacts, there is an increasing need to understand the intercultural differences and similarities between Russian and Chinese youth, particularly in significant areas
O. E. Iatsevich +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
MEDIA PORTRAIT OF CONTEMPORARY RUSSIAN HOUSEHOLD IN SOCIO-PHILOSOPHICAL DISCOURSE
Вестник Донского государственного технического университета, 2018 The research results of the influence of mass communication media on the modern Russian household are generalized. The transmission of the family values by the contemporary mass media is analyzed.
Irina A. Kairova
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Global Changes of Family Unit in Modern Russia
Astra Salvensis, 2019 The current study is relevant due to the necessity to analyze transformations in modern family-marriage relations. The objective of the study is to consider inevitability of the given transformations as an integral part of natural changes in modern ...
Igor Vasilevich MALIMONOV +6 more
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