Results 31 to 40 of about 2,010,923 (253)

Normative Solidarity: Narratives of Solo Parent Multigenerational Caregivers in Selected Resettlement Areas in Cavite

open access: yesPsikoislamika
This study explored the experiences of solo parents who provide simultaneous support to their minor children and senior parents in selected resettlement areas in Cavite, Philippines.
Krishia Marie Villaluz Tabogon   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Examination of gender differences in attitude towards children [PDF]

open access: yesزن در فرهنگ و هنر, 2016
Due to the decreased growth rate and aging population, communities population has become a controversial issue. This subject has led many thinkers to understand the factors influencing fertility decline.
Amir Rastegar Khaled, Sajedeh Moghadami
doaj   +1 more source

Don Bosco and the Conditions of Pre-industrial Youth in His Times

open access: yesSeminare, 2022
The year 2015 marks the bicentenary of the birth of Saint John Bosco, whom Pope John Paul II designated as the father and teacher of youth. As members of the Salesian Family worldwide comme- morate this event, they do so with the intention of starting ...
Joseph Boenzi
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

The role of social projects in the development of family values in Russian small territories (based on the results of a sociological study in the Perm region) [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Cоциология. Политология
The article is devoted to the study of social projects aimed at developing family values in modern Russia, using the example of the sociological study of small territories of Perm region.
Voronova, Kseniya A.   +1 more
doaj   +1 more source

Family values of the youth of the Penza region: marriage and parenthood

open access: yesИзвестия высших учебных заведений. Поволжский регион: Общественные науки, 2022
Background. The changes in Russia in the sphere of family and marriage affect key value systems. The transformation of family values affects such functional systems of the family as parenthood, marriage and kinship. The attitude of young people towards
A.M. Ivanishko
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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