Results 61 to 70 of about 2,010,923 (253)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TRADATIONAL FAMILY VALUES AND CONTEMPORARY CHALLENGES OF AZERBAIJANIS [PDF]

open access: yesمجلة الاجتهاد للدراسات القانونية والاقتصادية, 2019
Under conditions of globalization traditional moral values in the modern Azerbaijani family are subjected to change. The characteristic of a family's activity, which is a complicated social phenomenon, is determined by a number of different conditions ...
Dr. Nuruzade sahla
doaj  

How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis – designing a prospective observational study in South Africa

open access: yesFrontiers in Pharmacology, 2016
Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes.
Tanja Kastien-Hilka   +9 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Exploring Community Based Responses and the Natural History of a Drug Market

open access: yesSocial Work and Society, 2015
Previous studies portray open drug market neighborhoods as uniformly poor, urban, socially disorganized, with weak informal social control. Further, open drug market neighborhoods appear sui genesis.
Wes Abercrombie, Mitchell Mackinem
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Family Values

open access: yes, 2013
This chapter concerns the intersection of art and power in the Roman world, as well as how we study Roman art. A common emphasis on the formal qualities of so-called Romanized art has created the perception of art as symbolic of the success of Rome and of the acquiescence of indigenous peoples to its rule.
openaire   +2 more sources

Family leisure facilities as a driver of city development

open access: yesUrbis et Orbis: Mikroistoriâ i Semiotika Goroda
The study examines the issue of developing family leisure facilities within the context of urban space management. The relevance of this problem lies in research indicating that families engaged in family leisure activities tend to be stronger ...
Oksana Gomazova   +2 more
doaj   +1 more source

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