ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan +9 more
wiley +1 more source
Relationship between parental physical activity and adolescents' physical activity: the mediating role of family physical activity support. [PDF]
Liang F, Ding H, Gong P, Zhang L, Han L.
europepmc +1 more source
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source
Choices and support during serious illness in the surgical intensive care unit. [PDF]
Sanchez SE, Kang D.
europepmc +1 more source
Prevalence patterns and associated factors of psychological distress among Syrian refugees in middle eastern host countries: a scoping review. [PDF]
Khataybeh S, Ahmad M, Momani F.
europepmc +1 more source
"A Tangible Gift of Intangible Value": The Process of Legacy Creation Among Older Adults. [PDF]
Neller SA +5 more
europepmc +1 more source
Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder. [PDF]
Justice CM +11 more
europepmc +1 more source
Engaging Latinx or Hispanic-Identifying Families in Science Education: A Longitudinal Intervention Study. [PDF]
Jiang S +3 more
europepmc +1 more source

