Results 81 to 90 of about 2,120,661 (302)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Coherence between values and successor socialization: Facilitating family business continuity [PDF]
The problem of CEO succession is critically important yet unique and distinct from that of turnover at other levels. Research in management agrees with the findings in family business research regarding the preference for an insider as successor, more ...
Garcia Alvarez, Ercilia, Lopez, Jordi
core
Internal market orientation and work-family balance\ud in family businesses [PDF]
, 2016 This research paper aims at investigating the importance of work-family balance (WFB) on family businesses from Andalusia (Spain) and its impact on job satisfaction and employees’\ud commitment.
Soares, Anabela +18 more
core +1 more source
Frontiers in Public HealthIntroductionSouth Korea faces a declining total fertility rate (0.72 in 2023) alongside rising infertility rates. Infertility is often interpreted within a pronatalist sociocultural context emphasizing marriage, parenthood, and traditional gender role ...
Miok Kim, Hyeon Sik Chu, Su Jeong Yi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Families, life events and family service delivery [PDF]
, 2012 Life events or transitions are understood to be circumstances that have an unsettling element for individuals (and from a systemic perspective, for family members also).
Lixia Qu +3 more
core
Models of youth’s family relations in Penza region
Известия высших учебных заведений. Поволжский регион: Общественные наукиBackground. The Russian family is going through a difficult period of its devel-opment, characterized by a number of trends such as the normalization of cohabitation, the postponement of marriage and childbirth, and the popularization of “childfree ...
A.M. Ivanishko
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source