Results 81 to 90 of about 9,991,757 (291)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
TRADATIONAL FAMILY VALUES AND CONTEMPORARY CHALLENGES OF AZERBAIJANIS [PDF]
مجلة الاجتهاد للدراسات القانونية والاقتصادية, 2019 Under conditions of globalization traditional moral values in the modern Azerbaijani family are subjected to change. The characteristic of a family's activity, which is a complicated social phenomenon, is determined by a number of different conditions ...
Dr. Nuruzade sahla
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Frontiers in Pharmacology, 2016 Introduction: Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes.
Tanja Kastien-Hilka +9 more
doaj +1 more source
Do family values and reproductive health knowledge influence reproductive health-promoting behaviors in married women? A cross-sectional survey. [PDF]
Korean J Women Health Nurs, 2022 Yun SJ, Kim HY.
europepmc +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Exploring Community Based Responses and the Natural History of a Drug Market
Social Work and Society, 2015 Previous studies portray open drug market neighborhoods as uniformly poor, urban, socially disorganized, with weak informal social control. Further, open drug market neighborhoods appear sui genesis.
Wes Abercrombie, Mitchell Mackinem
doaj
Family leisure facilities as a driver of city development
Urbis et Orbis: Mikroistoriâ i Semiotika GorodaThe study examines the issue of developing family leisure facilities within the context of urban space management. The relevance of this problem lies in research indicating that families engaged in family leisure activities tend to be stronger ...
Oksana Gomazova +2 more
doaj +1 more source