Results 121 to 130 of about 9,981,389 (290)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Global Changes of Family Unit in Modern Russia
Astra Salvensis, 2019 The current study is relevant due to the necessity to analyze transformations in modern family-marriage relations. The objective of the study is to consider inevitability of the given transformations as an integral part of natural changes in modern ...
Igor Vasilevich MALIMONOV +6 more
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
How Team Science Is Documented and Described in Published Family Medicine Research
Purpose: Increasingly emphasized by leaders in family medicine and primary care research, team science is an approach to research that requires clear documentation for replicability. Here, we report the approach to documenting team science in 2 US family
Armin, Julie S. +4 more
core +1 more source
Вестник университета, 2019 The article is devoted to the study of family values of pensioners of the Republic of North Ossetia-Alania. The study found that the family is the main value of the older generation.
V. Tarchenko
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Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
MEDIA PORTRAIT OF CONTEMPORARY RUSSIAN HOUSEHOLD IN SOCIO-PHILOSOPHICAL DISCOURSE
Вестник Донского государственного технического университета, 2018 The research results of the influence of mass communication media on the modern Russian household are generalized. The transmission of the family values by the contemporary mass media is analyzed.
Irina A. Kairova
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