Results 131 to 140 of about 10,526,884 (291)

Work Values and Family Business Choices

open access: yes, 2007
Family businesses are very dependent on decision-making by the owner-manager. The personal beliefs and values system of the decision-maker (owner) create a framework that guides adoption and rejection of goals and consequent behavior; similarly, beliefs ...
CUBICO, Serena
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Global Changes of Family Unit in Modern Russia

open access: yesAstra Salvensis, 2019
The current study is relevant due to the necessity to analyze transformations in modern family-marriage relations. The objective of the study is to consider inevitability of the given transformations as an integral part of natural changes in modern ...
Igor Vasilevich MALIMONOV   +6 more
doaj  

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Values of children and family models of adolescents: An eleven-culture study

open access: yes, 2008
Starting from Kagitcibasi's (2007) conceptualization of family models, this study compared N = 2961 adolescents' values across eleven cultures and explored whether patterns of values were related to the three proposed family models through cluster ...
Trommsdorff, Gisela, Mayer, Boris
core  

OLDER GENERATION ROLE IN THE PRESERVATION OF TRADITIONAL FAMILY VALUES (ON THE REPUBLIC EXAMPLE NORTHERN OSSETIA-ALANIA)

open access: yesВестник университета, 2019
The article is devoted to the study of family values of pensioners of the Republic of North Ossetia-Alania. The study found that the family is the main value of the older generation.
V. Tarchenko
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

Breaking Stereotypes by Obtaining a Higher Education: Latinas\u27 Family Values and Tradition on the School Institution [PDF]

open access: yes, 2010
Higher education is a way to be able to reach the American Dream and help pursue a professional career. The American Dream is a common ideology in the Latino community. Low wage labor in the United States was a way to obtain that American Dream.
Gomez Cervantes, Andrea
core  

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