Results 61 to 70 of about 5,761,106 (281)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Family values [PDF]

open access: yesNursery World, 2015
D’une maniere assez inattendue, la majorite des travailleurs immigres originaires d’Afrique du Nord et d’Afrique de l’Ouest loges dans les foyers ne voient pas dans la retraite l’occasion d’un retour definitif dans leur pays d’origine. Une approche croisant le genre, l’âge, la generation et l’origine ethnique permet de comprendre la facon dont ils ...
openaire   +2 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Frobenius map for quintic threefolds

open access: yes, 2008
We calculate the matrix of the Frobenius map on the middle dimensional cohomology of the one parameter family that is related by mirror symmetry to the family of all quintic threefolds.Comment: 19 pages, discussion of $p$-adic zeta values ...
Shapiro, I.
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Intergenerational transmission of traditional family values among the Turkic-speaking peoples of Dagestan

open access: yesИсторическая этнология
The article is devoted to the study of the system of traditional family values among the Turkic-speaking peoples living in the lowland part of Dagestan.
Madina B. Gimbatova
doaj   +1 more source

There Goes the Neighborhood: The Effect of Single-Family Mortgage Foreclosures on Property Values [PDF]

open access: yes, 2005
This report shows that foreclosures have a significant negative effect on neighborhood property values. Although foreclosures have long been considered a problem associated with FHA loan programs, recent research has shown that the explosion in ...
Daniel Immergluck, Geoff Smith
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Family values and well-being of adolescents in two-parent and divorced Russian families: A study in a small town and a metropolis

open access: yesRUDN journal of Sociology
The article considers family values and subjective well-being of adolescents in divorced and two-parent families, based on the survey of 14-17-year-olds in Saint Petersburg and the city of Tosno in the Leningrad Region. The study showed that adolescents’
O. N. Bezrukova, V. A. Samoylova
doaj   +1 more source

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